ENHANCING THE INTERNATIONAL MOLECULAR EXCHANGE (IMEX): PROVIDING AN IMPROVED COMMUNITY-ORIENTED MOLECULAR INTERACTIONS RESOURCE

加强国际分子交换（IMEX）：提供改进的面向社区的分子相互作用资源

• 批准号: 10157852
• 负责人: Matteo Pellegrini
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10157852
• 关键词: Address; Basic Science; Big Data; Big Data to Knowledge; Binding; Biological; Collaborations; Communities; Complex; Custom; Data; Data Analyses; Data Set; Databases; Deposition; Disease; Ensure; FAIR principles; Focus Groups; Goals; Grant; Human; Individual; International; Knowledge Discovery; Lead; Literature; Maintenance; Malignant Neoplasms; Manuals; Measures; Mediating; Metadata; Methods; Modeling; Molecular; Mutation; Outcome; Pathway Analysis; Pathway interactions; Post-Translational Protein Processing; Process; Production; Protein Databases; Proteins; Provider; Publications; Quality Control; Records; Registries; Regulation; Research; Research Personnel; Resources; Retrieval; Scientist; Set protein; Site; SwissProt; Text; Training; Translational Research; Triage; Update; data curation; design; experimental study; human disease; human interactome; improved; indexing; individualized medicine; innovation; interest; member; novel; outreach; research study; shared database; tool; web services; web site

Project Summary The IMEx Consortium (http://www.imexconsortium.org/) is an international collaboration between major public interaction data providers which captures experimental data through literature curation and deposition by bench scientists. IMEx member databases share and coordinate their curation efforts, using a central registry (IMExCentral: https://imexcentral.org/icentral/) to manage the selection of articles in order to provide a single, non-redundant, consistently-annotated set of protein interactions. In contrast to other currently active interaction databases, IMEx curators follow a detailed curation model which captures information on experimental methods and biologically important details such as essential binding regions and post-translational modifications, as well as mutations and their effect on protein interactions. This allows downstream users to analyze protein interaction networks and their regulation in normal and disease states. In this proposal we seek support for the continuation and extension of IMEx activities related to the curation and provision of interaction data with special emphasis on human interactome. Over the next five years, we will (1) augment the IMEx interaction dataset by curating information from at least 4000 new publications, providing tens of thousands of human protein interactions; (2) disseminate new and existing IMEx interaction records through a new, consortium-wide IMEx Protein Interaction Resource, which will include an interactive web site, a standards-compliant PSICQUIC web-service and ftp download site (customized subsets of the data will be provided to our long term collaborators, Reactome, UniProtKB and GO Consortium); (3) provide training for existing and new user communities on the use of protein interaction data and network analysis of cancer-related `big data'.

项目摘要 IMEX联盟(http://www.imexconsortium.org/)是主要公众之间的国际合作 交互数据提供者，通过BASE的文献整理和存储来捕获实验数据 科学家们。IMEX成员数据库使用中央登记处共享和协调其管理工作 (IMExCentral：https://imexcentral.org/icentral/)来管理文章的选择，以便提供单一的、 无冗余、一致注释的一组蛋白质相互作用。与其他当前活动交互相比 数据库，IMEX策展人遵循详细的策展模型，该模型捕获了实验方法的信息 以及生物学上重要的细节，如必要的结合区和翻译后修饰 AS突变及其对蛋白质相互作用的影响。这使得下游用户可以分析蛋白质的相互作用 网络及其在正常和疾病状态下的调节。 在这项建议中，我们寻求对继续和延长与馆藏有关的国际监测系统活动的支持。 以及提供特别强调人类交互作用组的交互数据。在未来五年，我们将 (1)通过收集至少4000份新出版物的信息，扩充IMEX互动数据集，提供 数以万计的人类蛋白质相互作用；(2)传播新的和现有的IMEX相互作用记录 通过一个新的联盟范围的IMEX蛋白质相互作用资源，其中将包括一个互动网站，一个 符合标准的PSICQUIC Web服务和ftp下载站点(数据的定制子集将 提供给我们的长期合作伙伴，Reactome、UniProtKB和Go Consortium)；(3)为 关于使用蛋白质相互作用数据和癌症相关网络分析的现有和新的用户社区 ‘大数据’。