Biobehavioral characterization of infant rhesus monkeys

描述（由申请人提供）：从幼年开始，生物体就表现出行为和生理反应、气质、情感和个性模式的变化，这是一组重叠的结构，称为“生物行为组织”。“这些模式出现在生命的早期，随着时间的推移非常稳定。越来越多的文献关注这种变异的起源及其对各种健康结果的影响。这种个性化的方法在个性化医疗领域的发展中是显而易见的，这种方法也越来越多地被应用于更多的应用环境中，包括在圈养非人灵长类动物的管理中。在加州国家灵长类动物研究中心，我们已经开发了一个生物行为评估（BBA）程序，以表征婴儿恒河猴的生物行为组织。工商管理硕士课程包括一个高度标准化的，长达25小时的方案，包括a）收集行为数据，以评估记忆力，对轻微挑战的反应能力，以及与新物体互动的意愿; B）对5-羟色胺转运蛋白和单胺氧化酶-A基因启动子区域的多态性进行基因分型; c）评估下丘脑-垂体-肾上腺系统的调节; d）测量常规血液学参数。除了为科学研究提供数据库外，BBA计划还有助于我们自己中心的非人灵长类动物资源的知识和改进，并且已发表的研究也为美国其他灵长类动物设施的管理人员提供了重要信息。提出了以下四个具体目标：1.继续进行生物行为评估，并将这些数据提供给CNPRC的管理人员以及CNPRC和其他机构的合格科学人员; 2.将炎症的生物标志物，即C反应蛋白，纳入BBA计划，并检查该标志物与其他BBA指标以及健康结果之间的关系; 3.继续研究BBA措施变化的原因和后果，以更好地了解生物行为组织如何受到管理程序的影响，并确定生物行为组织是否预测异常行为结果; 4.通过内展工作（专注于CNPRC的个人教育和培训）和外展工作（针对更大的非人灵长类动物行为管理社区），改善重要的群体管理相关发现的传播。

DESCRIPTION (provided by applicant): From an early age, organisms display variation in patterns of behavioral and physiological reactivity, temperament, emotionality, and personality, a set of overlapping constructs referred to as "biobehavioral organization." These patterns appear early in life and are remarkably stable over time. A growing literature, has focused on the origins of this variation as well as its consequences for a variety of health outcomes. Such an individualized approach is evident in development of the field of personalized medicine, and this approach is becoming increasingly adopted in more applied settings as well, including in the management of captive nonhuman primates. At the California National Primate Research Center we have developed a BioBehavioral Assessment (BBA) Program to characterize biobehavioral organization in infant rhesus monkeys. The BBA Program involves a highly standardized, 25-hour-long, protocol that includes a) collecting behavioral data to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of the serotonin transporter and monoamine oxidase-A genes; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. In addition to providing a database for scientific studies, the BBA Program contributes to the knowledge and improvement of the nonhuman primate resource at our own center, and published studies provide important information to management staff at other primate facilities in the United States as well. The following four specific aims are proposed: 1. Continue performing the BioBehavioral Assessment, and make these data available to management staff at CNPRC and qualified scientific staff at CNPRC and other institutions; 2. Incorporate into the BBA program a biomarker of inflammation, namely C-reactive protein, and examine the relationship between this marker and other BBA measures, as well as health outcomes; 3. Continue to examine causes and consequences of variation in BBA measures to better understand how biobehavioral organization is affected by management procedures, and to determine whether biobehavioral organization predicts abnormal behavior outcomes; 4. Improve dissemination of important colony management-related findings via both inreach efforts (focusing on education and training of individuals at CNPRC), and outreach efforts (for the larger nonhuman primate behavior management community).