Pathology and Biorepository Core

德克萨斯大学MD安德森分校翻译研究的一个基本组成部分 癌症中心脑癌孢子是涉及人体组织的重点转化研究的行为 和血液标本，允许研究靶组织和正常组织的生物学，并评估 治疗对靶组织和正常组织的影响以及对特定相关生物标志物的调节的影响。的 病理学和生物储存中心收集、处理和保存来自以下组织的人体组织标本： 并将这些组织和组织来源的原代胶质瘤干细胞（GSC）分散到孢子中 investigators.它一直是现有的SPORE项目的有效资源，这些项目是大量组织- 并将继续在未来拟议的SPORE项目中发挥这一作用。 病理学和生物储存核心的具体目标是： 目的1维持和加强肿瘤组织和匹配血液标本的储存库， 在MD安德森癌症中心接受治疗的中枢神经系统（CNS）肿瘤患者 目的2提供SPORE中使用的组织样本的全面组织学表征 项目，包括患者标本和动物实验肿瘤;迅速分发 组织标本交给SPORE研究人员进行分析，并提供研究解释方面的专业知识 在SPORE项目内的组织切片上进行 目标3提供集中服务，包括生物标志物的免疫组化表征， 组织阵列的设计和构建以及肿瘤样品的原代GSC培养。 目标4支持一个全面的、前瞻性的交互式数据库， 在MD安德森癌症中心接受治疗或评估的CNS肿瘤患者的病理学数据 目标5通过共享组织资源促进SPORE间的合作 相关性（参见说明）：不要超过所提供的空间。 对脑癌的研究取决于从患者身上获得的肿瘤样本的可用性。这些 样品和DNA、RNA、蛋白质和来自它们的细胞（例如GSC）是任何生物学行为的基础。 翻译程序该核心提供了患者样本，这是理解和治疗的关键 脑瘤

A fundamental component of the translational research of the The University of Texas MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue- dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific objectives of the Pathology and Biorepository Core are these: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central.nervous system (CNS) tumors receiving care at MD Anderson Cancer Center Objective 2 Provide comprehensive histologic characterization of tissue samples used in SPORE projects, including specimens from patients and experimental tumors in animals; expeditiously distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction and primary GSC culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at MD Anderson Cancer Center Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources RELEVANCE (See instructions): DO NOT EXCEED THE SPACE PROVIDED. Research into brain cancer depends on the availability of tumor samples obtained from patients. These samples and the DNA, RNA, proteins, and cells derived from them (e.g. GSCs) are the foundation of any translational program. This Core provides the patient samples that are key to understanding and curing brain tumors.