Basic applications for total-body PET in oncology

摘要： EXPLORER联盟，通过转型R 01和大量商业 投资，开发了2米长的全身PET扫描仪。该设备有可能大大提高 通过（a）显著减少扫描时间，（B）显著 图像质量的改善，（c）给药活动的显著减少和（d）全身覆盖。 该提案旨在回答这一新设备在以下方面提出的基本问题 当前临床肿瘤学应用空间：（1）可以多快地执行扫描以获得标准诊断 使用全身PET成像;（2）屏气PET是否可行;（3）扫描仪是否支持 25-给予的放射性示踪剂活性的倍数减少;（4）是否有价值延迟成像太多 注射后的时间点比当前实践晚，以及（5）如果获得图像质量的改善， 使用标准注射剂量和扫描时间具有临床实用性。 我们将从加州大学戴维斯分校的临床肿瘤人群中招募360例受试者; 具体而言，受肺癌、淋巴瘤和黑色素瘤影响的受试者初次转诊进行PET/CT扫描 将在开始治疗前入组分期。 我们希望EXPLORER全身PET扫描仪能够进行类似的研究。 诊断质量优于传统PET/CT扫描仪， 相当于标准剂量的1/25。此外，我们预测，屏气检查将是 在EXPLORER上可行。我们还预测，在EXPLORER上进行非常晚的时间点成像将是可行的 导致损伤显著性的潜在增益。最后，与一支高素质的团队合作， 凭借肿瘤学、放射治疗、放射学和病理学方面的专业知识，我们将收集初步数据， 与传统PET/CT相比，高质量EXPLORER扫描在肿瘤成像中的附加价值 扫描仪

Abstract: The EXPLORER Consortium, through funding via a Transformative R01 and substantial commercial investment, has developed a 2-meter long total body PET scanner. This device has the potential to significantly alter the clinical application of PET through (a) substantial reduction in scan times, (b) substantial improvements in image quality, (c) substantial reduction in administered activity and (d) total-body coverage. This proposal aims to answer the basic questions that this new equipment raises with respect to the current clinical oncology application space: (1) how fast a scan can be performed to obtain standard diagnostic images using total-body PET; (2) whether breath-hold PET is feasible; (3) whether the scanner will support a 25-fold reduction in administered radiotracer activity; (4) whether there is value in delaying imaging to much later time-points after injection than current practice and (5) if the improvements in image quality obtained using standard injected doses and scan times have clinical utility. We will enroll 360 subjects from the clinical oncologic population seen at University of California, Davis; specifically, subjects affected by lung cancer, lymphoma and melanoma referred for PET/CT scan initial staging will be enrolled before starting treatment. We expect that the EXPLORER total-body PET scanner will be able to perform studies of similar diagnostic quality to conventional PET/CT scanners in approximately a minute or using a reduced dose corresponding to 1/25th of the standard dose. In addition we predict that breath-hold examinations will be feasible on EXPLORER. We also predict that very late time point imaging will be feasible on EXPLORER resulting in potential gains in lesion conspicuity. Finally, in collaboration with a team of highly-qualified team with expertise in oncology, radiation therapy, radiology and pathology, we will collect initial data to assess the added value of high-quality EXPLORER scans in oncologic imaging compared to conventional PET/CT scanners.