Molecular Mechanisms of Immune Tolerance

项目摘要/摘要 我们申请续签T32博士后培训计划，以支持5名博士后学员学习 免疫耐受和自身免疫的分子机制。培训人员包括一名高度 由28名教员组成的互动小组(社区中约70名免疫学家和首席研究人员) 专注于B和T细胞的发展，抗原识别，曲目的发展，编辑沉默， 缺失和无能，以及增强对肿瘤的免疫力的策略。培训在加州大学进行。 科罗拉多州(UC)及其附属公司国家犹太人健康(NJH)。所有培训人员都是以下组织的主要或次要成员 免疫学和微生物学系和加州大学免疫学研究生课程的成员。这个 自从我们上次竞争续签以来，这份申请的教职员工数量增加了40%，促使我们 将我们对实习生支持的请求从4个增加到5个。教职员工人数的增加反映了新的 为我们的机构提供教师，并在我们打算培训的领域扩大，如肿瘤免疫学和 翻译研究。 该项目由两名项目主任罗伯塔·佩兰达博士领导，她已成为 2017年，他将是主要的赠款联系人，约翰·坎比尔博士自 盗梦空间。这些联合董事在免疫耐受和自身免疫方面拥有专业知识，在这两方面都有研究 老鼠和人类。佩兰达博士也是造血人源化小鼠核心设施的负责人，而 坎比尔博士培养了60多名博士后和研究生，是一位杰出的教授和 免疫学和微生物学系主任兼UCSOM人类中心主任 免疫学和免疫治疗倡议。 博士后研究员将在申请后由招聘和任命委员会挑选支持 由实习生和导师提供。评选将基于功绩和建议的研究。受训人员将被要求 参加负责任的研究行为课程，每年参加一次，并在我们的周刊上发表 “研究进行中”论坛，并每年完成一份个人发展计划。评估 研究和职业指导的进展将由一个至少由3人组成的指导委员会提供 教职员工和实习生每6个月会面一次。该培训计划的目标是 向研究员提供关于免疫耐受和自身免疫的小鼠模型的全面知识，以及 对临床自身免疫有足够的了解，使他们能够开展富有成效的临床协作 翻译研究的纽带。这一培训计划仍然是免疫学的主要重点 特别是在落基山脉地区和整个美国的研究。

PROJECT SUMMARY/ABSTRACT We apply for renewal of a T32 postdoctoral training program to support 5 postdoctoral trainees studying molecular mechanisms of immunologic tolerance and autoimmunity. Training faculty include a highly interactive group of 28 faculty (among about 70 immunologists and principal investigators in our community) strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and strategies to enhance immunity to tumors. Training is performed at the University of Colorado (UC) and its affiliate National Jewish Health (NJH). All trainers are primary or secondary members of the Department of Immunology & Microbiology and members of the Immunology graduate Program at UC. The number of faculty on this application have increased by 40% since our last competitive renewal, prompting us to increase our request for trainee support from 4 to 5. The increase in faculty reflects recruitment of new faculty to our institution and broadening in areas in which we intend to train, such as tumor immunology and translational research. The program is headed by two Program Directors, Dr. Roberta Pelanda, who has become the co-director in 2017 and will be the primary grant contact, and Dr. John Cambier, who has directed the Program since its inception. These co-directors have expertise in immunological tolerance and autoimmunity with studies in both mice and humans. Dr. Pelanda is also the Director of the hematopoietic humanized mouse core facility, while Dr. Cambier has trained more than 60 postdocs and graduate students, and is a Distinguished Professor and Chairman of the Department of Immunology and Microbiology and the Director of the UCSOM Human Immunology and Immunotherapy Initiative. Postdoctoral fellows will be selected for support by the Recruitment and Appointing Committee after application by the trainee and mentor. Selection will be based on merit and research proposed. Trainees will be required to take a course in the Responsible Conduct in Research, to attend and present once a year in our weekly “Research in Progress” forum, and to complete each year an Individual Development Plan. Evaluation of progress of research and career guidance will be provided by a mentoring committee consisting of at least 3 faculty members and meeting with the trainee once every 6 months. The goal of this training program is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. This Training Program continues to be a major focus for immunological research in the Rocky Mountain region in particular and the USA in general.