利用泵浦探针光学成像改善黑色素瘤的诊断-猫眼课题宝

利用泵浦探针光学成像改善黑色素瘤的诊断

批准号：

9189685

负责人：

Warren S Warren

金额：

$32.14万

依托单位：

DUKE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-01-02 至 2017-12-31

来源：

https://reporter.nih.gov/project-details/9189685

关键词：

Age Algorithmic Analysis Algorithms Archives Biochemical Pathway Biological Assay Biopsy Categories Chemicals Classification Clinical Color Databases Detection Diagnosis Diagnostic Disease Employee Strikes Entropy Excision Eye Gender Goals Gold Grant Health Care Costs Hematoxylin and Eosin Staining Method Heterogeneity Histopathology Image Image Analysis Imaging technology Immunohistochemistry Italy Lasers Lead Lesion Malignant Neoplasms Medical Melanins Melanosomes Methods Microscope Microscopy Mole the mammal Molecular Morbidity - disease rate Morphology Neoplasm Metastasis Nevus Outcome Pathologist Patient Care Patient-Focused Outcomes Patients Pigments Principal Component Analysis Protocols documentation Publishing Pump Research Resolution Retrospective Studies Sampling Savings Sentinel Lymph Node Biopsy Skin Slide Spatial Distribution Staging Staining method Stains System Testing Text Thick Thinness Time Tissues Translational Research United States National Institutes of Health Validation Variant Woman Work base cancer biomarkers cancer diagnosis cost diagnostic accuracy eumelanin imaging modality improved in vivo insight male melanoma men mortality novel optical imaging pheomelanin predict clinical outcome public health relevance skin lesion translational medicine two-photon

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中文摘要

翻译

描述(申请人提供)：这项研究的目标是使用泵浦-探测显微镜系统来发现发生和没有发生转移的黑色素瘤之间具有统计学意义的差异。这些信息将被用于开发自动分类算法，以找到具有强大预测能力的健壮的分子和结构特征。这些洞察力将使黑色素瘤和前哨淋巴结活检的回顾性研究成为可能，并可用于验证研究结果。到该项目结束时，预计将有统计上的显著证据表明，泵浦-探测显微镜可以显著提高组织病理学的诊断准确性。

英文摘要

DESCRIPTION (provided by applicant): The goal of the research is to use a pump-probe microscopy system to find statistically significant variations between melanomas that did and did not develop metastases. This information will be used to develop automated classification algorithms to find robust molecular and structural features with strong predictive power. These insights will enable a retrospective study of melanoma and sentinel node biopsies, that can be used to validate the findings. By the end of the project, it is expected that there will be statistically significant evidence that pump-probe microscopy can substantially improve the diagnostic accuracy of histopathology.

期刊论文(20)

专著(0)

科研奖励(0)

会议论文

Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump–Probe Microscopy

使用泵探针显微镜分析结膜黑素细胞病变中的黑色素结构和生化成分

DOI： 10.1167/tvst.8.3.33

发表时间： 2019

期刊：

Translational Vision Science & Technology

影响因子： 3

作者：