The ACT annual symposium: a living, learning, national collaboratory to advance Alzheimer's disease and brain aging research

项目摘要/摘要 阿尔茨海默病(AD)的诊断和死亡人数正在上升--目前有540万人患有阿尔茨海默病 仅在2016年，就有70万人死亡。没有万无一失的方法来预防、早期发现或 解药。成人思维变化(ACT)研究招募了5000多名65岁以上的成年人 1994年，每两年跟踪一次新的痴呆症和阿尔茨海默病的诊断。行动数据有助于谋生， 学习合作实验室，作为AD和Brain的宝贵科学资源服务于研究界 老龄化研究。在过去的四年里，我们每年举办一次ACT研讨会，以突出新的ACT 资源、创新研究成果和跨学科合作。我们已经用最少的资源做到了这一点 来自ACT家长U01的支持。这笔会议赠款将为我们日益增长的研讨会提供新的支持 接下来的三年。我们的会议资助的具体目标是：1)促进适当的科学 使用和理解ACT数据；2)促进跨科学学科、机构和 研究；以及3)为正在进行和计划中的工作提供反馈的机会，包括正在进行的分析 和新的拨款想法，特别是对初级调查人员。这一新的资金来源将为我们提供支持 将我们的会议地点转移到更大、技术更先进的设施。它还将提供旅行 为从外地来的调查人员提供津贴，以便我们可以将我们的触角伸向新的外部 调查人员。我们预计未来的会议(2017年夏末、2018年和2019年在西雅图举行， 华盛顿)将涵盖老龄化和痴呆症研究的热点话题，如弹性、成像、痴呆症 亚型、分子表型和创伤性脑损伤--ACT对其有重要意义的主题 贡献。从长远来看，扩大我们的ACT研讨会将增加对ACT现场实验室的使用， 推进阿尔茨海默病和脑老化研究。

Project Summary/Abstract Alzheimer's disease (AD) diagnoses and deaths are on the rise – 5.4 million are currently living with the disease and 700,000 will die in 2016 alone. There is no sure-fire method for prevention, early detection, or cure. The Adult Changes in Thought (ACT) study has recruited over 5,000 adults over the age of 65 since 1994, and follows them every 2 years for new dementia and AD diagnoses. ACT data contribute to a living, learning co-laboratory, which serves the research community as a valuable scientific resource for AD and brain aging research. For the past four years, we have held an annual ACT Symposium to highlight new ACT resources, innovative research findings, and cross-disciplinary collaborations. We have done this with minimal support from the ACT parent U01. This conference grant will provide new support for our growing symposia for the next three years. The specific objectives of our conference grant are to: 1) promote appropriate scientific use and understanding of ACT data; 2) promote collaborations across scientific disciplines, institutions, and studies; and 3) provide opportunities for feedback on ongoing and planned work including analyses in progress and new grant ideas particularly for junior investigators. This new funding source will provide support for us to move our conference location to a larger, more technologically advanced facility. It will also provide travel stipends for investigators traveling from out of town so that we may extend our reach to new external investigators. We anticipate that future conferences (in late summer of 2017, 2018, and 2019 in Seattle, Washington) will cover hot topics in aging and dementia research such as resilience, imaging, dementia subtypes, molecular phenotypes, and traumatic brain injury – topic to which ACT is making significant contributions. Long term, expanding our ACT symposia will increase use of the ACT living laboratory, and advance AD and brain aging research.