Terry Beirn CPCRA Clinical Trials Unit

描述(由申请人提供)：Terry Beirn CPCRA临床试验单位由7个临床研究站点的研究人员和研究人员组成，他们在艾滋病毒、肝炎、结核病和预防研究以及患者护理方面拥有超过20年的经验，并在过去6年中建立了有效和高效的合作记录。CPCRA CTU的目标是在预防和治疗艾滋病毒、肝炎和结核病方面进行临床相关研究；招募人口统计、地理和社会经济上不同的人群参加临床试验；并与受艾滋病毒、肝炎或结核病影响的社区成员合作，开展这项研究议程。Terry Beirn CPCRA CTU将在招生和科学专长方面为ACTG和HPTN领导小组做出重大贡献。通过ACTG，CPCRA CTU将为治愈和/或实现艾滋病毒功能性治愈的战略的多个随机临床试验、改善结核病诊断和治疗的研究、治愈传染性肝炎的战略、改善非传染性并存的治疗或预防战略以及评估针对艾滋病毒感染的新型治疗干预措施的战略做出贡献。通过HPTN，CPCRA CTU将评估和优化预防艾滋病毒感染的综合战略，并评估和优化最有希望的暴露前预防(PrEP)方案。目标人群包括H1V阳性人群以及艾滋病毒携带者和血清转换高危人群，特别是高危亚群。CPCRA CTU行政办公室位于华盛顿特区退伍军人事务医疗中心，是申请组织乔治华盛顿大学的校外分支机构。CTU首席调查员和行政办公室工作人员为7个临床研究站点提供监督、协调、培训、技术援助和监管支持，其中6个附属于ACTG(丹佛公共卫生、亨利·福特医院、休斯顿艾滋病研究小组、弗吉尼亚联邦大学、韦恩州立大学)，1个附属于HPTN(乔治·华盛顿大学)。 相关性：鉴于艾滋病毒、结核病和肝炎的全球感染持续流行，目前对这些疾病的预防和治疗进行研究势在必行。隶属于Terry Beirn CPCRA CTU及其7个临床研究站点的研究人员经验丰富、能力强，并致力于为减轻这些感染给人们生活带来的负担做出重大贡献。

DESCRIPTION (provided by applicant): The Terry Beirn CPCRA Clinical Trials Unit is composed of investigators and research staff at 7 Clinical Research Sites with over 20 years of experience in HIV, hepatitis, tuberculosis and prevention research and patient care and with an established record of effective and efficient collaboration over the past 6 years. The CPCRA CTU aims to conduct clinically relevant research in the prevention and treatment of HIV, hepatitis, and tuberculosis; to enroll a demographically, geographically, and socio-economically diverse population of individuals into clinical trials; and to carry out this research agenda in clse collaboration with community members who are themselves affected by HIV, hepatitis, or tuberculosis. The Terry Beirn CPCRA CTU will make significant contributions to the ACTG and HPTN leadership groups, both in enrollment and in scientific expertise. Through the ACTG, the CPCRA CTU will contribute to multiple, randomized clinical trials in strategies to cure and/or achieve functional cure of HIV, studies to improve the diagnosis and treatment of tuberculosis, strategies to cure infectious hepatitis, and strategies to improve the treatment of, or prevent, non-infectious co-morbidities and evaluate novel therapeutic interventions targeting HIV infection. Through the HPTN, the CPCRA CTU will evaluate and optimize integrated strategies to prevent HIV infection, and evaluate and optimize the most promising pre-exposure prophylaxis (PrEP) regimens. Targeted populations include those who are H1V+ as well as those who are HIV- and at-risk for seroconversion, especially high-risk subgroups. The Administrative Office of the CPCRA CTU located at the Veterans Affairs Medical Center in Washington, DC, is an off-campus affiliate of the applicant organization, the George Washington University. The CTU Principal Investigator and Administrative Office staff provide oversight, coordination, training, technical assistance and regulatory support for 7 Clinical Research Sites, 6 affiliated with the ACTG (Denver Public Health, Henry Ford Hospital, Houston AIDS Research Team, Virginia Commonwealth University, Wayne State University) and 1 with HPTN (George Washington University). RELEVANCE: Ongoing research on prevention and treatment of HIV, tuberculosis and hepatitis is imperative given the continued prevalence of these global infections. Investigators affiliated with the Terry Beirn CPCRA CTU and its 7 Clinical Research Sites are experienced, competent, and committed to make significant contributions to reduce the burden of these infections on people's lives.