Training in Molecular& Genetic Epidemiology of Cancer

描述(由申请人提供)：本提案旨在对R25T癌症教育和职业发展计划进行竞争性更新，以获得癌症遗传学和分子流行病学(GMEC)的博士后培训。当前的癌症研究时代正在为理解致癌的遗传和环境原因提供非凡的工具。最大限度地使用这些工具需要来自科学家团队的投入，他们混合了 背景，包括分子生物学、肿瘤学、医学、遗传学、流行病学和生物统计学。在这些领域接受跨学科教育的个人对 这样的团队的成功。特别是，它们可以作为完成一些最有希望的研究所需的综合工作的渠道。然而，大多数培训机会的重点性质为调查人员提供了有限的机会，以获得连接这些学科的知识。为了解决这个问题，我们建议第三次更新目前的GMEC培训计划。请注意，对于上一次续签，研究部非常支持这一计划，在第一次(也是唯一一次)审查中给出了18分。该计划的总体具体目标是为杰出的博士后候选人提供一系列教学和研究机会，以促进他们作为癌症遗传和分子流行病学跨学科“领域”的独立研究人员的职业生涯。导师和研究培训机会将继续来自旧金山湾区的主要学术和研究机构，包括加州大学旧金山和伯克利分校、Kaiser Permanente、斯坦福大学和加州癌症预防研究所。该计划特别适合R25T资助机制，因为它在多个不同领域的交叉点培训科学家。更具体地说，GMEC项目以高度互动的方式将一群来自癌症研究、分子生物学、遗传学、流行病学和生物统计学的导师和学员融合在一起。该计划由三个主要部分组成：1)涵盖关键学科及其交叉的专业核心课程；2)额外的教育经验，以补充他们的研究、教育背景和兴趣；以及3)有多名导师的重点研究项目。每个受训人员还将被要求通过撰写一份模拟的NIH提案来扩展他们的研究经验。在这项计划中接受培训的个人将拥有破译癌症原因的关键技能，最终提供关于这种复杂疾病的预防和治疗的宝贵知识。

DESCRIPTION (provided by applicant): This proposal is for a competitive renewal of a R25T Cancer Education and Career Development Program for post-doctoral training in Genetic and Molecular Epidemiology of Cancer (GMEC). The current era of cancer research is providing extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. Using these tools to their fullest extent requires input from teams of scientists with a mixture of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with trans-disciplinary education across these fields are crucial to the success of such teams. In particular, they can serve as the conduit for the integrated work necessary to accomplish some of the most promising research. However, the focused nature of most training opportunities provides limited opportunities for investigators to obtain the knowledge that bridges these disciplines. To address this issue, we propose renewing for a third time the current GMEC training program. Note that for the previous renewal, Study Section was extremely supportive of this Program, giving it a score of 18 on the first (and only) review. The overall specific aim of this program is to offer a set of instructional and research opportunities o exceptional postdoctoral candidates in order to promote their careers as independent researchers in the interdisciplinary "field" of genetic and molecular epidemiology of cancer. Mentors and research training opportunities will continue to come from major academic and research institutions in the San Francisco Bay Area, including the University of California San Francisco and Berkeley, Kaiser Permanente, Stanford University, and the Cancer Prevention Institute of California. This program is uniquely suited to the R25T grant mechanism because it trains scientists at the intersection of multiple distinct fields. More specifically, the GMEC program blends together in a highly interactive fashion a group of mentors and trainees from cancer research, molecular biology, genetics, epidemiology, and biostatistics. The program is defined by three main components: 1) a specialized core curriculum that covers the key disciplines and their intersections; 2) additional educational experiences to complement their research and educational background and interest; and 3) focused research projects with multiple mentors. Each trainee will also be required to extend their research experience by writing a mock NIH proposal. Individuals trained in this program will have the skills vital to deciphering the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.