2018 Bones and Teeth Gordon Research Conference and Gordon Research Seminar

摘要 骨和牙齿戈登研究会议(B&T GRC)已经有60多年的历史了 与骨骼和牙齿生物学及疾病研究相关的多个学科的领军人物一起分享 在这方面，我们有权公布最新的、往往是未公布的结果，并进行广泛和建设性的讨论。在过去 十年来，戈登研究研讨会(GRS)在GRC前一天举行，大大增加了 实习生和早期职业调查人员的参与，促进了NEXT- 世代科学家和资深调查人员。2018年GRC和GRS将继续并加强这一点 这是传统。通过有组织的科学演示、正式和非正式讨论以及海报 会议为期6天(1天GRS加5天GRC)，旨在展示 与正常和疾病状态有关的骨骼和牙齿研究的最新进展，以及 促进跨学科协作。自2014年和2016年的上一次会议以来，实地见证了 对骨骼作为全身生理学不可或缺的组成部分的研究兴趣激增，以及这样的研究 已经发现了骨骼和神经元或代谢系统之间的新的调节电路。 这些发现强调了骨骼和整体健康之间的密切联系。此外，新的 骨骼和牙齿干细胞的细胞起源和分子调控与正常的关系 动态平衡或衰老正在以创纪录的速度提供，对罕见骨骼疾病的研究已经产生 在机械理解和潜在疗法方面都取得了前所未有的进步。因此，要捕捉 为了推动该领域的进一步创新，2018年会议特别寻求强调 综合骨骼生理学，骨骼代谢调节，骨骼和骨骼的前沿研究 牙齿干细胞，罕见的骨骼疾病和骨骼老化，以及其他重要话题。无论是科学上的 GRC和GRS的内容和协作精神直接与多个NIH的任务相一致 研究所包括NIDCR、NIA、NIAMS和NIDDK。

Abstract The Bones and Teeth Gordon Research Conference (B&T GRC) has had over 60 years of history in bringing together leaders in a variety of disciplines relevant to studies of bone and tooth biology and diseases to share the latest and often unpublished results, and to engage in extensive and constructive discussion. In the past decade, the Gordon Research Seminar (GRS) held one day before the GRC has greatly increased the participation of trainees and early career investigators and promoted close interactions between next- generation scientists and senior investigators. The 2018 GRC and GRS will continue and strengthen this tradition. Through structured scientific presentation, formal and informal discussions as well as poster sessions over the course of 6 days (1 day GRS plus 5 days GRC), the meetings are designed to showcase the latest advancement in skeletal and dental research in relation to both normal and disease states, and to catalyze cross-disciplinary collaborations. Since the last meetings in 2014 and 2016, the field has witnessed a surging interest in studying the skeleton as an integral component of whole-body physiology, and such studies have uncovered novel regulatory circuitries between the skeletal and the neuronal or the metabolic systems. Such findings have underscored the intimate connection between skeletal and overall health. In addition, new insights about the cellular origin and molecular regulation of skeletal and dental stem cells in relation to normal homeostasis or aging are being provided at a record pace, and studies of rare bone diseases have produced unprecedented progress in both mechanistic understanding and potential therapeutics. Therefore to capture the momentum and to propel further innovation in the field, the 2018 meetings particularly seek to highlight the cutting-edge research in Integrative Skeletal Physiology, Metabolic Regulation of the Skeleton, Skeletal and Dental Stem Cells, Rare Bone Diseases and Skeletal Aging, among other important topics. Both the scientific content and the collaborative spirit of the GRC and GRS are directly aligned with the missions of multiple NIH institutes including NIDCR, NIA, NIAMS and NIDDK.