Improving Calibration of Wearable Blood Pressure Monitoring

项目摘要 血压（BP）控制是帮助预防心血管疾病（CVD）的关键策略之一。 传统的基于袖带的血压测量在临床上100多年来没有根本改变， 对于临床人员和患者来说，每次测量都需要大量的时间和精力，同时还 无法捕捉到瞬时血压波动当前动态血压监测（ABPM） 这些技术基于相同的（基于袖带的）原理，因此仍然是突兀的，需要过多的 每次测量的时间，并且无法捕捉瞬时BP波动。我们以前的工作表明， 颞浅动脉（STA）眼压测量是可穿戴、非侵入性血压监测的最佳方法：它 适合于长时间使用，可以内置成小形状因数，可以提供连续波形 血压测量，并与最新的电子健康记录（EHR）和信息兼容 技术.然而，与其他非侵入性、无袖带BP技术一样，STA眼压测量存在以下问题： 重大的校准挑战。这个R21项目的目标是开发一个可穿戴的BP监测模块， 并研究和整合两种新的方法来改善STA眼压计的校准：多传感器 STA眼压计建模，以及抑制压力漂移的自适应校正。为了使STA眼压计 为了使这种方法在临床上更加可行，我们的目标是将所需的校准间隔延长到至少4小时。 我们将对金标准连续BP监测系统进行验证研究，并进行 使用双传感器STA眼压计进行可穿戴式长期（12小时）监测的可行性研究，应用我们的 组合校准方法。稳定的STA眼压测量BP测量将提供革命性的一步 从目前已有100年历史的BP测量标准向前发展，并将促进 为患有心血管疾病症状和风险的人提供健康管理。

Project Abstract Blood pressure (BP) control is one of the key strategies to help prevent cardiovascular disease (CVD). Conventional cuff-based, BP measurement in the clinic has not fundamentally changed in over 100 years, requiring significant time and effort per measurement for both clinical personnel and the patient, while also being unable to catch transient BP fluctuations. Current ambulatory blood pressure monitoring (ABPM) technologies are based on the same (cuff-based) principles and hence remain obtrusive, require excessive time per measurement and are unable to catch transient BP fluctuations. Our previous work suggests that the superficial temporal artery (STA) tonometry is an optimal approach for wearable, unobtrusive BP monitoring: it is suitable for long-duration use, can be built into a small form-factor, can provide continuous waveform measurements of BP, and is compatible with the latest electronic health records (EHR) and information technologies. As with other non-invasive, cuffless BP technologies, however, STA tonometry suffers from significant calibration challenges. The goal of this R21 project is to develop a wearable BP monitoring module, and investigate and integrate two novel approaches to improve the calibration of STA tonometry: multi-sensor STA tonometry modeling, and adaptive correction of hold-down pressure drift. To make the STA tonometry approach more clinically viable, our goal will be to extend the required calibration interval to at least 4 hours. We will conduct validation studies against gold-standard continuous BP monitoring systems, and also conduct a feasibility study of wearable long-term (12-hour) monitoring using dual-sensor STA tonometry, applying our combined calibration approaches. Stable STA tonometry BP measurements will provide a revolutionary step forward from the current 100-year-old BP measurement standard, and will facilitate major improvements in health management for people who suffer from symptoms and risks of CVD.