Training in Immunodermatology

 描述（由申请人提供）：这是科罗拉多大学安舒茨医学院（UCAMC）皮肤科30年来资助的一项非常成功的培训补助金的重新提交。该计划开始作为免疫皮肤病学培训工具，但在过去的15年里，随着该部门的研究重点扩大，已经发生了很大的变化。UCAMC皮肤病学系研究计划的显着扩展提供了一个绝佳的机会来重组自2012年以来一直没有资金的培训补助金的范围和重点。新的PI Dennis Roop将领导一个令人印象深刻的多学科培训师和导师团队，目前24名培训教师中有16名是新的。这个培训师和导师团队将为博士前和博士后学员提供为期2年的培训计划。这项培训补助金的重点将类似于我们的NIAMS资助的P30 UCAMC-SDRC题为“皮肤病的分子分析，建模和纠正”。该SDRC强调了解人类自身免疫性，炎症性，发育性，代谢性和遗传性皮肤病的分子基础，以及在遗传和表型水平上模拟这些疾病的遗传工程小鼠模型的开发。此外，临床前模型（包括小鼠模型）将用于评估干细胞治疗方法的可行性。 从历史上看，这是一个非常成功的培训补助金，为临床科学家的学术生涯做好准备，刺激皮肤科和其他部门的科学家之间的广泛研究合作，并支持皮肤科部门的高效研究计划。在1984年至2006年期间完成2年研究奖学金的24名学员中，14名（58%）最初获得学术任命，2名在其他环境中继续研究，8名进入私人执业。其中六人目前在UCAMC担任教职。2007年以来的7名受训人员中，6人在完成培训后担任其他研究职位。其中一人是皮肤科系的助理教授，并获得了K 01资金，以及其他3个地方和国家来源的资金。 该计划的总体目标是为学员在学术机构的皮肤生物学研究中成功的学术生涯做好准备。我们的计划将主要培养博士后研究员（博士，医学博士和医学博士/博士），为他们成功过渡到独立的研究资金，并最终独立的研究生涯做好准备。 该培训补助金将每年支持2个博士前和4个博士后培训职位。导师实验室的研究培训将辅以丰富的实质性计划，包括研究研讨会，正在进行的研究，相关主题的教学讲座和道德培训。该计划的候选人招聘将由一个组织良好的行政结构管理，并将包括一个强大的计划，以吸引服务不足的少数民族。

 DESCRIPTION (provided by applicant): This is the resubmission of a highly successful training grant funded for 30 years from the Department of Dermatology at the University of Colorado Anschutz Medical Campus (UCAMC). This program began as an Immunodermatology training vehicle, but has greatly changed in the past 15 years as the research focus in this Department has broadened. The remarkable expansion of the research program in the Department of Dermatology at UCAMC provides a perfect opportunity to restructure the scope and focus of this training grant, which has been unfunded since 2012. Dennis Roop, the new PI, will lead an impressive multidisciplinary team of trainers and mentors, 16 of 24 of the current training faculty are new. This team of trainers and mentors will provide a 2 year training program for pre-doctoral and postdoctoral trainees. The focus of this training grant will be similar to tha of our NIAMS-funded P30 UCAMC-SDRC entitled "Molecular Analysis, Modeling and Correction of Skin Diseases". This SDRC emphasizes understanding the molecular basis of human autoimmune, inflammatory, developmental, metabolic and genetic skin diseases and development of genetically engineered mouse models which mimic these disorders at both the genetic and phenotypic levels. Further, preclinical models (including mouse models) will be utilized to assess the feasibility of stem cell approaches to therapy. Historically, this has beena highly successful training grant, preparing clinical scientists for academic careers, stimulating extensive research collaborations between scientists in Dermatology and other departments, and supporting a highly productive research program in the Department of Dermatology. Of the 24 trainees who have completed a 2 year research fellowship between 1984 and 2006, 14 (58%) initially obtained academic appointments, two have continued research in other settings, and 8 have entered private practice. Six have current faculty positions at UCAMC. Of the 7 trainees since 2007, 6 are in other research positions after completing training. One of these is an assistant professor in the Department of Dermatology and has obtained K01 funding, as well as funding from 3 other local and national sources. The overall objective of this program is to prepare trainees for a successful academic career in cutaneous biology research at academic institutions. Our program will primarily train postdoctoral fellows (PhD, MD and MD/PhD) to prepare them for successful transitions into independent research funding and eventually independent research careers. This training grant will support 2 pre-doctoral and 4 postdoctoral training positions per year. Research training in preceptor's labs will be supplemented with a substantial program of enrichment including research seminars, research in progress, didactic lectures on relevant topics, and training in ethics. Recruitment of candidates for this program wil be managed by a well-organized administrative structure and will include a robust plan to attract underserved minorities.