ANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASE

 描述（由申请人提供）：这是一个有竞争力的续约申请，以继续支持德克萨斯大学西南医学中心（UTSW）儿科系的儿童健康研究职业发展奖（CHRCDA）计划。UTSW及其儿科系的理想定位是提供支持性的环境，专门的导师，关键的核心资源，最重要的是，成为该奖项的最终受益者的有才华的临床医生-科学家的流。我们的目标是激励和使这些年轻的科学家成为下一代富有想象力，独立和复杂的研究人员，专注于对婴儿和儿童一生至关重要的疾病。我们相信，我们的CHRCDA计划是唯一有资格实现这一目标的原因如下：1）我们已经组装了一个培训教师，提供巨大的学科多样性，跨越九个大学部门和四个自治中心，并在同一时间统一集中在我们的CHRCDA的发展主题; 2）我们已经确定的研究生物过程不仅对儿科至关重要，而且还可以利用现有的优势， UT西南大学基础科学和临床部门之间建立良好的研究和培训合作; 3）认识到在年轻医生中促进研究事业的必要性比以往任何时候都更为重要，我们部门致力于从早期阶段确定最佳候选人，并为他们提供成功发展为独立儿科医生所需的鼓励和资源-科学家与发现的热情;和4）尽管其四年的短期课程，我们的计划已经证明了它的能力，以实现由美国国立卫生研究院为CHRCDA建立的目标，证明了我们的所有三个毕业的学者在获得K 08或同等联邦支持无论是在他们参与该计划或一年内毕业的成功。在UT西南的CHRCDA计划将支持一次最多四名学者，每个接受两年的任命（可延长至三年）。在参与该计划期间，学者将遵循个性化的研究指导计划，并将在导师的监督下将至少80%的精力用于严格的研究计划。每位学者的经验将继续强调识别引人注目的临床相关科学问题，保持项目重点，创造性的实验设计，最先进的技术和周到的早期职业指导。

 DESCRIPTION (provided by applicant): This is a competitive renewal application for continued support of the Child Health Research Career Development Award (CHRCDA) Program in the Department of Pediatrics at the University of Texas Southwestern Medical Center (UTSW). UTSW and its Department of Pediatrics are ideally positioned to provide the supportive environment, the dedicated mentors, the critical core resources, and, most importantly, the stream of talented clinician-scientists that become the ultimate beneficiaries of this award. Our goal is to motivate and enable these young scientists to become the next generation of imaginative, independent, and sophisticated investigators focused on the diseases of major importance to infants and children throughout their lifetimes. We believe that our CHRCDA Program is uniquely qualified to accomplish this goal for the following reasons: 1) we have assembled a training faculty that offers enormous subject diversity, spanning nine university departments and four autonomous centers, and is at the same time uniformly focused on the developmental theme of our CHRCDA; 2) the biologic processes that we have identified for study are not only critically important to pediatrics, but also leverage existing strengths and well-established research and training collaborations between basic science and clinical departments at UT Southwestern; 3) recognizing that there has been no other time when the need to promote research careers among young physicians has been more crucial, our Department is committed to identifying the best candidates from an early stage and providing them with the encouragement and resources requisite to successful development into independent pediatric physician-scientists with a passion for discovery; and 4) despite its short course of four years, our Program has demonstrated its ability to achieve the goals established by NIH for the CHRCDA as evidenced by the success of all three of our graduating scholars in obtaining K08 or equivalent federal support either during their participation in the Program or within one year of their graduation. The CHRCDA Program at UT Southwestern will support a maximum of four Scholars at a time, each receiving an appointment of two years (which may be extended to three). During their participation in the Program, the Scholars will follow a personalized plan for research instruction and will dedicate a minimum of 80% of their effort to a rigorous research plan under the supervision of a mentor. Each Scholar's experience will continue to emphasize the identification of compelling clinically-relevant scientific questions, maintenance of project focus, creative experimental design, state-of-the-art technology, and thoughtful early career guidance.