Biochemisty, Pathology, and Imaging Core

项目总结（见说明）： 核心B，生物化学，病理学和成像核心将继续服务于所有三个项目通过所有五年的计划。核心由三个单元组成：（1） 核心B的生物化学单位将对个别项目中的小鼠组织/血浆和培养细胞进行分析，以评估氧化应激、AGEs和其他与血管功能障碍和血管功能障碍有关的生化介质。(2)Core B的病理学部门将对小鼠组织进行病理学分析。该单位将为所有3个项目提供免疫组织化学和半定量标准化服务。 分析。该单位将对动脉粥样硬化（动脉粥样硬化（主动脉根部动脉粥样硬化和主动脉正面评估）、血管生成（项目2-3）和心肌梗死面积（项目3）进行分析。 (3)新成立的影像组将采用先进的新设备，进行新的影像技术，用于动脉粥样硬化和细胞凋亡（项目1）和血管生成（项目2）的分子影像研究。

PROJECT SUMMARY (See instructions): Core B, the Biochemistry, Pathology and Imaging Core will continue to serve all three Projects through all five years of the Program. The core is composed of three units: (1) The Biochemistry Unit of Core B will perform assays on tissue/plasma of mice and cultured cells in the individual projects for assessment of oxidative stress, AGEs and other biochemical mediators linked to RAGE and vascular dysfunction. (2) The Pathology Unit of Core B will perform pathological analysis of mouse tissues. This Unit will serve all 3 projects for standardization of immunohistochemistry and semiquantitative analyses. The Unit will perform analysis of atherosclerosis (aortas (atherosclerosis at the aortic root and en face assessment of aorta), angiogenesis (Project 2-3) and myocardial infarction size (Project 3). (3) The newly-formed Imaging Unit will perform novel imaging techniques using state-of-the-art new equipment for molecular imaging studies in atherosclerosis and apoptosis (Project 1) and angiogenesis (Project 2).