Cancer Population Sciences (CPS)

项目概要/摘要：癌症人口科学 癌症人口科学（CPS）计划汇集了40名教师，代表12个部门， 达特茅斯盖泽尔医学院（盖泽尔），达特茅斯-希区柯克医疗中心（DH）和白色 河路口VT退伍军人管理局医疗中心（VA），与三个相关的研究兴趣 中央CPS计划主题：1）生命过程癌症流行病学，2）转化人口科学，和3） 卫生保健提供科学。CPS计划的共同目标是：1）进行基于人口的 了解癌症发生和结果的分子、行为和环境基础的研究 2）为改善癌症筛查的政策和实践建立科学基础， 从预防到生存的整个癌症连续体的护理提供质量和健康结果; 3）设计和测试干预措施，并促进降低癌症风险和癌症负担的政策， 集水区，全国和超越。同行评审的癌症相关研究直接费用支持目前 总计870万美元，其中NCI资金占32%（280万美元），直接成本总额为960万美元。十六（16） CPS计划成员目前共有17个CCSG定义的R 01等效奖项。使用相同的 2014年NCI对癌症相关直接成本的定义，同行评议的癌症相关研究直接成本为78 与2014年相比，增长了2%，但每个成员的资金增长了6%（40名成员为216，234美元，57名成员为204，161美元 成员）。自2015年以来，CPS计划有994篇与癌症相关的出版物，31%（311篇）是计划内的， 9%（93人）是跨计划的，75%（743人）是与其他机构的研究人员合作。基于926的影响 数据显示，20%（181）是高影响力期刊（即，影响因子>8）。与2014年相比， 出版物从29%增加到31%，高影响力从16%增加到20%。之前 2018年计划重组，我们的两个人口科学计划具有跨计划出版率 分别为13%和19%，与他们在2014年报告的范围（13-19%）相匹配。CPS项目负责人 为未来的发展制定了明确的方案层面和主题层面的计划。其中包括增强的、跨学科的 由多个学科的高级教师指导初级研究人员;开发和支持 使工作组（如肥胖症、微生物组、乳腺癌、烟草监管和地理空间研究） 建立跨人口科学及其他学科的合作; 培训项目。

Project Summary/Abstract: Cancer Population Sciences The Cancer Population Sciences (CPS) Program brings together 40 faculty, representing 12 departments at Dartmouth’s Geisel School of Medicine (Geisel), Dartmouth-Hitchcock Medical Center (DH) and the White River Junction VT Veterans Administration Medical Center (VA), with research interests relevant to the three central CPS Program themes: 1) Life course cancer epidemiology, 2) Translational population science, and 3) Health care delivery science. The shared goals of the CPS Program are to: 1) conduct population-based studies to understand the molecular, behavioral and environmental basis of cancer occurrence and outcomes across the life course; 2) establish a scientific basis for policies and practices that improve cancer screening, quality of care delivery, and health outcomes across the cancer continuum, from prevention to survivorship; and 3) design and test interventions and promote policies that reduce cancer risk and cancer burden in our catchment area, nationally and beyond. Peer-reviewed cancer-related research direct cost support currently totals $8.7M, with NCI funding representing 32% ($2.8M) and total direct costs summing to $9.6M. Sixteen (16) CPS Program Members currently have a total of 17 CCSG-defined R01-equivalent awards. Using the same NCI definition of cancer-related direct costs in 2014, peer-reviewed cancer-related research direct costs are 78 % compared to 2014, but per Member funding is up 6% ($216,234 for 40 Members vs. 204,161 for 57 Members). Since 2015, the CPS Program has 994 cancer-related publications, 31% (311) intra-programmatic, 9% (93) inter-programmatic, and 75% (743) with investigators from other institutions. Based on 926 with impact data, 20% (181) were high impact journals (i.e., impact factor >8). Compared to 2014, intra-programmatic publications have increased, to 31% from 29%, and high impact has increased, to 20% from 16%. Prior to the 2018 Program reorganization, our two population science programs had inter-programmatic publication rates of 13% and 19%, which matched the range (13-19%) they reported in 2014. The CPS program leaders have defined program-level and theme-specific plans for future growth. These include enhanced, trans-disciplinary mentorship of junior investigators by senior faculty in multiple disciplines; the development and support of subject workgroups (e.g. obesity, microbiome, breast cancer, tobacco regulatory and geospatial research) to build collaborations that cross the disciplines of population science and beyond; and continued growth of training programs.