Novel Combinations of Radiation and Immunotherapy

作为一名接受过放射外科专业培训的放射肿瘤学家，以及在癌症生物学和普通免疫学方面的研究生和博士后培训，我研究的最终目标是找到将免疫疗法(IT)与放射疗法(RT)相结合的有效方法，以促进全身肿瘤控制，同时实现局部肿瘤控制。为了这个目标，我领导了NCI Rob颅外立体定向全身放射治疗(SBRT)计划的发展，我是NCI的主要Rob助理研究员，与Tim Greten和Austin Duffy(NCI/TGIB)合作进行NCI的结直肠肝转移(15-C-0021)和胰腺(15-C-0027)RT+IT研究。最终，我们计划研究免疫疗法试验(如这些RT+IT试验、NCI VB疫苗试验和NCI其他肿瘤免疫治疗试验)中应答者和非应答者的EV亚集，将EV亚集签名转换为生物信息，可用于我们患者的个性化和适应性治疗。

As a radiation oncologist with specialized training in radiosurgery and graduate and postdoctoral training in both cancer biology and general immunology, the ultimate goal of my research is to discover effective ways to combine immunotherapies (IT) with radiation therapy (RT), to promote systemic tumor control while achieving local tumor control. Toward this goal, I led the development of the NCI ROB extracranial Stereotactic Body Radiation Therapy (SBRT) program, and I am the primary ROB Associate Investigator working with Tim Greten and Austin Duffy (NCI/TGIB) on NCI's colorectal liver metastases (15-C-0021), and pancreas (15-C-0027) RT + IT studies. Ultimately, we plan to study EV subsets in responders and non-responders from immunotherapy trials (such as these RT + IT trials, NCI VB vaccine trials, and other tumor immunotherapy trials at NCI), to translate the EV subset signatures into biological information that could be used for personalized and adaptive treatments for our patients.