Comprehensive Genomics

综合基因组学共享资源 项目总结/摘要 综合基因组学是理解癌症的分子病理生理学和癌症的分子病理生理学的组成部分。 发现改进的诊断和治疗方法。Comprehensive Genomics共享资源 （基因组学）的罗格斯癌症研究所的新泽西（CINJ）是一个机构管理的共享资源 其目的是提供集中的、高质量的、具有成本效益的尖端细胞基因组分析， 组织中 这种共享资源在上一个资助期内得到了极大的扩展，现在位于罗格斯大学内。 University Cell and DNA Repository（RUCDR-Infinite Biologics），包括一个大型的下一代 测序技术。这一重组使CINJ能够解决下一步开发的建议- 通过利用现有的重要资源和仪器， RUCDR为癌症中心研究人员的需求服务。CINJ的两名训练有素、经验丰富的工作人员 成员仍然与共享资源，现在在RUCDR内工作，致力于服务的需要， 癌症中心成员。这两名工作人员向联合主任报告，提供当地咨询服务， 并安排无缝样本转移RUCDR拥有最先进的生物样品处理技术 仪器，机器人工作流程（包括用于从核酸样品处理的全自动机器人设施）， 酸提取到测序）、综合质量控制和一套测序平台。测序 数据通过闪存驱动器或电子方式传输回调查人员，通常与调查人员协调。 生物医学信息学共享资源。

COMPREHENSIVE GENOMICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT Comprehensive Genomics is integral to understanding the molecular pathophysiology of cancer and the discovery of improved diagnostics and treatments. The Comprehensive Genomics shared resource (Genomics) of Rutgers Cancer Institute of New Jersey (CINJ) is an Institutionally managed shared resource whose purpose is to provide centralized, high quality, cost-effective cutting edge genomic analyses of cells and tissues. This shared resource has been greatly expanded over the last grant period and now resides within the Rutgers University Cell and DNA Repository (RUCDR-Infinite Biologics) and includes a large suite of next-generation sequencing technologies. This reorganization allowed CINJ to address the suggestion to develop next- generation sequencing capabilities by leveraging the significant resources and instrumentation available at RUCDR to serve the needs of Cancer Center investigators. The two highly trained and experienced CINJ staff members remain with the shared resource and now work within RUCDR, dedicated to serving the needs of Cancer Center members. Both staff members report to the Co-Directors, provide local consultation services, and arrange for seamless sample transfer. RUCDR is home to state-of-the-art biosample-processing instrumentation, robotic workflows (including a fully automated robotics facility for sample handling from nucleic acid extraction to sequencing), integrated quality control, and a suite of sequencing platforms. Sequencing data is transmitted back to investigators either on flash drives or electronically, usually in coordination with the Biomedical Informatics shared resource.