Mentored Clinical Scientist Research Career Development Award

 描述（申请人提供）：本申请的目的是获得指导临床科学家研究职业发展奖（K08），以使申请人有足够的受保护时间来1）发展进行高质量卫生服务研究所需的统计和方法技能，2）发展研究设计和实施方面的额外技能，以及3）进一步发展领导和管理技能，以领导一个富有成效的研究团队。从长远来看，弗里德曼博士希望：1）使用管理数据集和大型临床试验的数据来确定次优护理和医疗保健变化的领域，2）在比较有效性研究的背景下确定最佳的cae改进策略，以及3）进行临床研究以评估质量改进举措的有效性和益处。具体来说，弗里德曼博士的计划包括专注于发展因果推理方法的专业知识，这是一个分析框架，将使他能够在自己的领域进行具有高度影响力的研究。通过正式的生物统计学培训，积极参与复杂数据集的分析，由Cande Ananth博士和Jason Wright博士密切指导，参加讲座，期刊俱乐部，会议和研讨会，并进行研究分析评估产时护理质量概述的应用程序，弗里德曼博士希望大大提高他作为研究人员的能力。Friedman博士已经确定了Wright博士和Ananth博士，因为他们在流行病学，生物统计学和健康结果研究方面的专业知识，以及他们成功指导初级教师的长期记录。Ananth博士是 一位国际知名的围产期流行病学家，其研究工作重点是开发和应用创新的统计方法来研究人类生殖。Jason Wright博士是一位妇科肿瘤学家、经验丰富的临床试验专家、翻译研究员和流行病学家。Wright博士和Ananth博士都致力于与Friedman博士密切合作。随着对生物统计学和研究方法的复杂性的了解的增加，弗里德曼博士将获得独立进行高质量健康结果研究的能力。他已经确定了一个高级顾问小组来监督他的进展，并将每季度与这个小组举行一次会议。本申请的研究策略是一项新的基于人群的护理质量研究，旨在评价产时护理质量的候选指标。Friedman博士指出，对产科实践的基线依从性知之甚少，这可能代表分娩和分娩期间的护理质量，以及医生，提供者和患者因素如何影响依从性。鉴于目前还没有就如何最好地衡量产科护理质量达成一致意见，迫切需要有效的分娩护理质量措施。弗里德曼博士的研究计划可能会导致临床相关和有用的发现，改善产妇护理。

 DESCRIPTION (provided by applicant): The purpose of this application for a Mentored Clinical Scientist Research Career Development Award (K08) is to allow the applicant sufficient protected time to 1) develop the statistical and methodological skills necessary to perform high quality health services research, 2) develop additional skills in study design and implementation, and 3) further develop leadership and management skills to lead a productive research team. In the long term, Dr. Friedman hopes to: 1) identify areas of sub-optimal care and health care variation using administrative datasets and data from large clinical trials, 2) identify optimal cae improvement strategies within the context of comparative effectiveness research, and 3) perform clinical research to assess the validity and benefit of quality improvement initiatives. Specifically, Dr. Friedman's plan includes a focus on developing an expertise in causal inference methodology, a framework of analysis that will allow him uniquely poised to perform high-impact research in his field. Through formal biostatistical training, active participation in analysis of complex datasets, close mentorship by Dr. Cande Ananth and Dr. Jason Wright, attending lectures, journal clubs, conferences, and symposia, and performing the research analysis evaluating intrapartum care quality outlined in the application, Dr. Friedman hopes to substantially enhance his capabilities as a researcher. Dr. Friedman has identified Dr. Wright and Dr. Ananth because of their expertise in epidemiology, biostatistics, and health outcomes research as well as their long track record of successfully mentoring junior faculty. Dr. Ananth is an internationally renowned perinatal epidemiologist whose research work focuses on developing and applying innovative statistical approaches to studies in human reproduction. Dr. Jason Wright is a gynecologic oncologist, experienced clinical trialist, translational researcher, and epidemiologist. Dr. Wright and Dr. Ananth are both committed to working closely with Dr. Friedman. With increased knowledge of the complexities of biostatistics and research methodology, Dr. Friedman will gain the ability to independently perform high-quality health outcomes research. He has identified a senior advisory panel to oversee his progress and will meet quarterly with this group. The research strategy for this application is a novel population-based care quality study evaluating candidate measures for quality of intrapartum care. To summarize the study, Dr. Friedman notes that little is known about baseline adherence to obstetric practices that may be representative of care quality during labor and childbirth and how physician, provider, and patient factors influence adherence. Given that there is no agreement on how to best measure the quality of obstetric care, valid measures of intrapartum care quality are urgently needed. With his excellent mentorship team, Dr. Friedman's research plan may result in clinically relevant and useful findings that improve maternal care.