National Resource for Translational and Developmental Proteomics

整体 摘要 国家翻译和发育蛋白质组学资源（NRTDP）提出了一系列 第二阶段的活动。在2015年推出并在每个国家建立功能计划后， P41 BTRR的使命，我们现在转向2020 - 2025年的拟议拨款期，以开发新的 技术，并通过使从业者能够分析蛋白质和许多合作者翻译它们， 来更深入地了解它们的生物学。与P41计划的变化一致，我们将重点放在 促进蛋白质组学的基础和临床研究，减少实践，将创新扩展到早期 自上而下的蛋白质组学的新实现的采用者，这本身对许多人来说是一个新概念， 遭遇我们还采用各种机制，包括企业合作伙伴关系、社区参与、培训 和传播，以确保可持续的影响，即使在日落后，这P41国家资源。 在启动我们的业务后，我们现在有三个新的技术研发项目，六个 新的驱动生物医学项目，一套高度动态的合作项目和一系列社区 参与活动，以继续在目前支持的P41资源中发挥我们的独特作用 的NIGMS。我们的资源所产生的技术和支持将继续为合作者提供 正交数据流，并进一步证明了比可能更精确地测量蛋白质的价值 与当代“自下而上”的蛋白质组学技术相结合。从心脏病到癌症研究， 神经学和年龄相关疾病的免疫学，蛋白质和蛋白质型的分析及其后， 翻译修饰将继续通过新的和细胞特异性的分子机制来揭示潜在的分子机制。 精确蛋白质组学的技术。这将使临床医生和细胞生物学家能够跨越四个主要疾病 地区，并以新的风格，以国际公认的卓越， 基于质谱的蛋白质组学，补充了全国现有的投资领域。的 合作者和培训活动的地理分布与成熟的资源相一致， 在2015年达到最初赠款建议中设想的业务水平。 西北大学在基础科学和人文科学两方面的环境都提供了很强的制度支持 以及大芝加哥地区的医学研究校园。利用专业蛋白质组学家团队 NRTDP拥有不同的背景和经验，已被证明是一个非常有能力的企业， 大力支持NIGMS获得的方案。作为一个单位，我们高度重视对 P41计划的精神和文字，并寻求与当前产品组合中的其他P41协同作用 由NIGMS和NIH支持。

Overall Abstract The National Resource for Translational and Developmental Proteomics, or NRTDP, proposes a constellation of activities in its second phase of operation. After launching in 2015 and establishing functional programs in each mission of a P41 BTRR, we now turn toward the proposed granting period from 2020 – 2025 to develop new technologies and translate them by enabling both practitioners to analyze proteoforms and many collaborators to understand their biology more deeply. Consistent with changes in the P41 program, we place major emphasis on enabling basic and clinical research in proteomics, reduction to practice to extend innovations to early adopters of new implementations of top-down proteomics, which is itself a new concept to many we encounter. We also embrace mechanisms including corporate partnerships, community engagement, training and dissemination to ensure a sustainable impact even after the sunset of this P41 National Resource. After booting up our operation, we now posit three new Technology Research and Development Projects, six new Driving Biomedical Projects, a highly dynamic set of collaborative projects and an array of Community Engagement activities to continue serving our unique role within the set of P41 Resources currently supported by NIGMS. The technology and support emanating from our resource will continue to provide collaborators with orthogonal data streams and further demonstrate the value of measuring proteins more precisely than is possible with current-generation technology of “bottom-up” proteomics. From heart disease to cancer research, neurology and age-related disorders to immunology, the analysis of proteins and proteoforms and their post- translational modifications will continue to unveil underlying molecular mechanisms through new and cell-specific technologies for precision proteomics. This will enable clinicians and cell biologists across four major disease areas, and significantly bolster American interests with an internationally-recognized excellence in a new style of mass spectrometry-based proteomics that complements existing areas of investment across the nation. The geographical distribution of collaborators and training activities are consistent with a mature resource that reaches the level of operation envisaged in the original grant proposal in 2015. The institutional support is very strong from an environment of Northwestern University on both its basic science and medical research campuses in the greater Chicago area. Leveraging a team of professional proteomicists with diverse backgrounds and experiences, the NRTDP has proven to be a highly capable enterprise that returns strongly on programmatic support received by NIGMS. As a unit, we place high value on attentiveness to the spirit and the letter of the P41 program, and also seek to synergize with other P41s within the current portfolio supported by the NIGMS and NIH.