Neuropathology Core

项目摘要：神经病理学核心！ 神经病理学核心是为了支持OADC的5个首要目标的总体具体目标：1) 通过组织机构促进和支持AD和相关疾病的创新研究和发现 支持丰富协作环境的基础设施；2)将资源集中到特定领域 重点：临床前痴呆和疾病活动性，强调年龄最大的老年人；有意义的标志 通过研究外周生物标志物、神经成像和持续的居家行为捕捉到的变化 监测；大脑老化和老年痴呆的神经病理学；新治疗方法的新测试；以及 改善有关痴呆症的教育和知识；3)通过良好的 描述研究参与者、生物标本、脑组织、数据提供和分析；4) 促进与阿尔茨海默病和相关疾病相关的国家研究共享空间；以及5)提供场所和 建立教育和培训新科学家的机制，并对主要利益攸关方进行教育和告知。 OADC的神经病理学核心关注从健康老龄化到痴呆症的转变，导致了 从认知完好的脑捐赠者和发育良好的脑捐赠者那里积累大量组织 老年痴呆症和较轻的损伤，其病理与 “典型的”阿尔茨海默氏症。结合临床和影像表现来理解这些变化 在这些个体中被提出为科学的“主旋律”，围绕着它来构建具体的目标。 这些是为了： 1.提供标准化的研究评估，同时提供诊断专业知识以 为OADC受试者提供死者家属和参与的医生 根据最新的标准化诊断标准，及时提供尸检报告。 2.通过收集、存储和分发高度可访问但受到适当保护的 精心准备的脑组织和神经病理数据的存储库，来自仔细和纵向 轻度认知障碍(MCI)或痴呆症以及非认知障碍患者的特征 使用各种方法的个人，以最大化对科学家的效用。 3.向病理学、神经学、心理学、精神病学和基础科学的学员传授 神经退行性疾病的神经病理学分类和与年龄相关的变化，以及导师 北卡罗来纳州的教师。 4.开发创新的新办法，最大限度地实现目标1至3的成就。

Project Summary: Neuropathology Core! The Neuropathology Core is aligned to support the overall specific aims of the OADC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related disorders through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well- characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The focus of the OADC’s Neuropathology Core on the transition from healthy aging to dementia has led to the accumulation of a large repository of tissue from cognitively intact brain donors and from those who develop dementia and milder impairments at a more advanced age, with pathologies that differ somewhat from those of “classic” Alzheimer’s disease. Understanding these changes in the context of the clinical and imaging findings in these individuals is proposed as the scientific “leitmotif” around which the Specific Aims are constructed. These are to: 1. Provide standardized research assessments while at the same time affording this diagnostic expertise to the population of OADC subjects by providing family members of the deceased and physicians involved in their care with timely autopsy reports based on the most current standardized diagnostic criteria. 2. Facilitate research by collecting, storing and distributing a highly accessible, but appropriately safeguarded, repository of well-prepared brain tissue and neuropathologic data from carefully and longitudinally characterized patients with mild cognitive impairment (MCI) or dementia as well as non-cognitively impaired individuals using a variety of methods that maximizes utility to scientists. 3. Teach trainees in pathology, neurology, psychology, psychiatry, and basic sciences the current methods of neuropathological classification of neurodegenerative diseases and age-related changes, and mentor faculty in NP. 4. Develop innovative new approaches to maximize achievements in Aims 1 to 3.