Tobacco Use Treatment Research for Vulnerable Populations

项目摘要/摘要 这份职业中期调查员奖(K24)的申请将提高候选人Adam博士的能力 莱文塔尔，经营一个致力于烟草使用治疗患者的富有成效的指导和科学计划 面向弱势人群的研究(POR)，包括患有行为健康共病的个人 和其他弱势群体。莱文塔尔博士将从事自己的培训和职业发展活动 这将提高他的科学技能和通过完成课程、参加研讨会和 与一群杰出的专业临床科学家合作者互动。计划的活动将得到优化 成功实现其在烟草使用治疗领域增加知识和技能的培训目标--结果： (1)临床试验方案设计和实施(即招募、保留、跟踪、治疗和评估 寻求治疗的患者)，(2)高级数据分析，(3)临床 试验设计方法，以及(4)指导。拟议的研究项目将使莱文塔尔博士和 他的受训人员利用现有的优势，以病人为导向，研究烟草的潜在机制 使用该研究方案并将其转化为临床治疗结果试验，其形式为：(目标1)新的试点 大剂量安非他酮对患有快感缺乏症相关精神病理的吸烟者的临床试验(目标2)一种新的 一项正在进行的戒烟试验的现有数据分析，该试验测试了伐伦克林和纳曲酮的联合应用 对酗酒吸烟者的治疗，以及(目标3)完成和提交其他资助的POR赠款。这个 提高莱文塔尔博士的指导能力的计划将涉及专门的时间和资源来招募和 培训初级教师、博士后、住院医师、研究生和本科生的健康知识 行为研究、临床心理学、精神病学、医学、社会工作等领域希望从事 以患者为导向的烟草使用研究。他将提供临床翻译研究领域的培训 方法、数据分析、数据解释、稿件准备、研究技巧、研究伦理和专业知识。 专业发展。指导将通过莱文塔尔博士的积极研究实验室进行，该实验室包括 4名初级教员，每个人都有自己的外部研究资金，并主持每周的个人和小组会议- Ings with导师，一个杂志俱乐部，以及一个外部演讲者系列。一项新的大学范围内的多所学校倡议 在南加州大学建立一个由莱文塔尔博士领导的合作成瘾科学研究所将为他提供额外的 与学员互动的机会来自多个不同的临床科学学科- 项目和计划。通过执行这个职业中期(K24)奖项中建议的活动，莱文塔尔博士将 处于最佳地位，培养以患者为导向的新一代高素质科研人员 IMPACT转化性治疗研究计划，减少脆弱人群的烟草负担。

PROJECT SUMMARY/ABSTRACT This application for a Mid-Career Investigator Award (K24) will advance the capacity of the candidate, Dr. Adam Leventhal, to operate a productive program of mentoring and science dedicated to tobacco use treatment patient oriented research (POR) with vulnerable populations, including individuals with behavioral health comorbidities and other disadvantaged groups. Dr. Leventhal will engage in his own training and career development activities that will improve his scientific skills and ability to mentor by completing coursework, attending workshops, and interacting with an outstanding group of expert clinical scientist collaborators. Planned activities will optimize success in his training goals of increasing knowledge and skills in the areas of tobacco use treatment-outcome: (1) clinical trial protocol design and implementation (i.e., recruiting, retaining, following, treating, and assessing treatment-seeking patients) with an emphasis on vulnerable populations, (2) advanced data analysis, (3) clinical trial design methodologies, and (4) mentoring. The proposed research projects will position Dr. Leventhal and his trainees to leverage existing strengths in patient-oriented research on the mechanisms underlying tobacco use and translate this research program to clinical treatment outcome trials in the form of: (Aim 1) A new pilot clinical trial testing high-dose bupropion for smokers with anhedonia-related psychopathology, (Aim 2) A new analysis of existing data from an ongoing smoking cessation trial testing varenicline + naltrexone combination therapy in heavy drinking smokers, and (Aim 3) Completion and submission of other funded POR grants. The plan to advance Dr. Leventhal’s mentoring capacity will involve dedicated time and resources for recruiting and training junior faculty, post-docs, medical residents, graduate students, and undergraduate students in health behavior studies, clinical psychology, psychiatry, medicine, social work, and other fields who wish to conduct patient-oriented tobacco use research. He will provide training in the areas of clinical translational research methods, data analysis, data interpretation, manuscript preparation, grantsmanship, research ethics, and pro- fessional development. Mentoring will occur through Dr. Leventhal’s active research laboratory, which includes 4 junior faculty who each have their own external research funding, and hosts weekly individual and group meet- ings with mentees, a journal club, and an external speaker series. A new university-wide multi-school initiative to develop a collaborative Institute for Addiction Science at USC led by Dr. Leventhal will provide him additional opportunities to interact with trainees form a wide variety of clinical science disciplines across numerous depart- ments and programs. By executing the proposed activities in this Mid-Career (K24) award, Dr. Leventhal will be optimally-positioned to develop a new talented generation of patient-oriented researchers engaged in a high- impact translational treatment research program that reduces the tobacco burden in vulnerable populations.