Mechanistic Effects of Health Coaching to reduce COPD Hospitalizations

项目摘要/摘要 这项拟议的研究的总体目标是进一步研究健康指导的各个方面，这是一种干预 这导致了第一个随机证据，即健康指导减少了慢性阻塞性疾病患者的再住院 肺部疾病(COPD)。对这种干预的机制效应的拟议研究将导致 干预如何发挥作用的理论框架。我们将进一步测试健康指导对 慢性阻塞性肺疾病严重症状患者的生活质量和日常体力活动 随机研究。总体目标：该提案将为罗伯托·本佐(Roberto Benzo)、医学博士和理科硕士提供受保护的时间来 延长他对未来NHLBI初级研究人员的指导，并扩大他的研究计划。特定的 目标：Benzo博士计划增加他指导肺部医学和危重病研究人员的时间 梅奥诊所的关怀计划，来自梅奥诊所生物医学科学研究生院的学生，以及 梅奥临床和翻译科学学者中心。他还将执行机械分析 他最近由NHLBI资助的随机研究确定了健康教练的好处，它减少了 住院治疗慢性阻塞性肺疾病，扩大健康指导在其他疾病中的有效性研究 一群人。资格：本佐博士是梅奥诊所的终身副教授，在 研究、出版和指导。他的K23职业发展奖，在哈佛大学接受流行病学培训 大学，随后的两个R01，和多个SBIR将他的背景发展为理想的候选人 用于此应用程序。他目前在梅奥诊所领导专注呼吸实验室，该实验室由美国国立卫生研究院资助，致力于 以病人为中心的肺部疾病研究。环境：拟议的K24赠款将通过 梅奥诊所肺和重症监护科，上一届美国排名第一 连续两年被《美国新闻与世界报道》报道。辅导计划：Benzo博士目前担任导师 初级教员、肺部和重症监护研究员、住院医师和研究生。几位受训者 都从事NHLBI研究，其中一人最近被NHLBI授予K23。学员： Benzo博士将在这笔赠款的帮助下巩固和扩大他的指导计划。该计划的 资源和声誉将吸引越来越多的最合格和最有前途的未来NHLBI 研究人员。培训：Benzo博士将接受实质性培训，以计划、执行和分析患者- 以研究为导向。研究：拟议的研究将建立在本佐博士之前的工作基础上，特别是 发表了他最近由NHLBI资助的R01研究的结果。意义：这笔赠款将有助于 开发下一代以患者为导向的NHLBI研究人员，并将支持正在进行的 研究实施干预措施，重点关注对患者重要的事情。

PROJECT SUMMARY/ABSTRACT The overarching goal of the proposed research is to study further aspects of health coaching, an intervention that led to the first randomized evidence that health coaching reduces re-hospitalizations in chronic obstructive lung disease (COPD). The proposed study of the mechanistic effect of this intervention will lead to the creation of a theoretical framework of how the intervention works. We will further test the effect of health coaching on the quality of life and daily physical activity of a patient with severe symptoms of COPD in a small but powered randomized study. General goals: The proposal will provide Roberto Benzo, MD, MSc, with protected time to extend his mentorship of junior future NHLBI researchers and also expand his research program. Specific aims: Dr. Benzo plans to increase his time mentoring investigators from the Pulmonary Medicine and Critical Care Program at Mayo Clinic, students from the Mayo Clinic Graduate School of Biomedical Sciences, and Mayo Center for Clinical and Translational Science scholars. He will also perform the mechanistic analysis of his recent NHLBI-funded randomized study identifying the benefits of health coaching which decreases hospitalizations for COPD and expand the study of the effectiveness of health coaching in another disease group. Qualifications: Dr. Benzo is a tenured Associate Professor at Mayo Clinic, with a strong record of research, publication, and mentoring. His K23 career development award, training in epidemiology at Harvard University, two subsequent R01s, and multiple SBIRs have developed his background as an ideal candidate for this application. He currently leads the Mindful Breathing Lab at Mayo Clinic, an NIH-funded lab devoted to patient-oriented research in lung disease. Environment: The proposed K24 grant will be executed through the Division of Pulmonary and Critical Care at Mayo Clinic, which was ranked #1 in the United States in the last two consecutive years by the U.S. News & World Report. Mentoring program: Dr. Benzo presently mentors junior faculty, pulmonary and critical care fellows, resident physicians, and graduate students. Several mentees are engaged in NHLBI research, including one who was recently awarded a K23 from the NHLBI. Mentees: Dr. Benzo will solidify and expand his mentoring program with the assistance of this grant. The program's resources and reputation will attract an increasing pool of the most qualified and promising future NHLBI researchers. Training: Dr. Benzo will undertake substantive training to plan, execute, and analyze patient- oriented studies. Research: The proposed research will build on Dr. Benzo's previous work, especially the published findings of his recent NHLBI-funded R01 study. Significance: This grant will facilitate the development of the next generation of NHLBI patient-oriented researchers and will support the ongoing research implementing the intervention that focuses on what matters to patients.