Chemical Biology of Infectious Diseases (CBID) Training Program

摘要 抗药性病原体数量的迅速增加和新的传染病威胁的出现 强调在制药业对新型抗菌疗法的迫切需求 在很大程度上放弃了这一领域的研发。学术研究机构已经开始 满足这一需求，但成功将需要训练有素的科学家将化学生物学技术应用于 微生物致病机理的研究。传染病化学生物学(CBID)培训计划 利用范德比尔特在化学生物学和微生物学方面的优势，让科学家做好迎接挑战的准备 抗菌药物靶标识别和药物发现。来自7个系的28名教导员 范德比尔特大学和范德比尔特大学医学中心都是该项目的导师。四 博士前学生将每年被选中，在他们的第二和第三年接受两年的支持 在五年计划中的学习。培训计划的亮点包括两个微生物的正式课程 病因学与化学生物学专业选修课的“小长假”研究 在合作者的实验室、研究和专业发展研讨会中的机会，互动 化学生物学系列研讨会，化学生物学年度研究研讨会，参加 传染病病例会议和抗生素管理计划，深入的实验室研究 经验，以及在一家大型制药公司的外部实习经验。研究项目强调 将化学生物学应用于微生物学研究的多学科方法，建议学生 至少两名CBID教官。因此，完成CBID培训计划的学生- 以核心学科为基础，并在互补领域接受过充分的培训，使他们能够有效地工作 在一个跨学科的环境中。

SUMMARY The rapidly increasing number of antibacterial-resistant pathogens and the emergence of new infectious threats underscore the desperate need for novel antimicrobial therapeutics at a time when the pharmaceutical industry has largely abandoned this area of research and development. Academic research institutions have begun to meet this need, but success will require scientists who are trained to apply the techniques of chemical biology to the study of microbial pathogenesis. The Chemical Biology of Infectious Diseases (CBID) Training Program exploits Vanderbilt’s strengths in chemical biology and microbiology and prepares scientists for the challenges of antimicrobial target identification and drug discovery. Twenty-eight faculty preceptors from seven departments in both Vanderbilt University and Vanderbilt University Medical Center serve as mentors for the Program. Four predoctoral students will be selected each year to receive two years of support during their second and third year of study in the five-year program. Highlights of the training program include formal coursework in both microbial pathogenesis and chemical biology, elective courses for specialized training, a “mini-sabbatical” research opportunity in a collaborator’s laboratory, research and professional development workshops, an interactive seminar series in chemical biology, an annual research symposium in chemical biology, participation in the infectious disease case conference and antibiotic stewardship program, an in-depth laboratory research experience, and an external internship at a major pharmaceutical company. Research projects emphasize a multi-disciplinary approach that applies chemical biology to the study of microbiology, and students are advised by at least two CBID preceptors. As a result, students who complete the CBID Training Program are well- grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in an interdisciplinary environment.