Summers in Children's Research for Diverse High School Students

“儿童研究中的暑假”(SCR)，亚利桑那大学斯蒂尔儿童健康科学中心 研究中心和钻石儿童医疗中心在这份为期5年的续签赠款提案中每年提供12 来自亚利桑那州的各种弱势初中/高中生和5名继续深造的本科生身临其境 分别提供为期8周和12周的基础、翻译和临床课程的暑期教育经验 广泛针对儿童和人类发展及相关疾病的研究。多学科项目 领导二人组包括一位国际知名的儿科医生，专门研究儿童胃肠道疾病 (分子机制和临床管理)和儿童和发育淋巴方面的国际专家 障碍和基因-表型相关性、多样性管道研究培训和探究课程创新。 他们将一起与影响儿童和产妇健康的充满活力的研究项目互动。基于 长期以来，联邦政府资助的多学科、多层次、弱势群体的医学院非常成功 学生研究计划和多样性/URM管道连续吸引了大量合格的申请者 在亚利桑那州周围，也是当地支持的部门。儿科高中生暑期计划，SCR过去5年 多年来一直在逐步开发一门独特的核心课程，包括在线组件和扩展的研究 在NICHD任务区的经验。暑期全日制研究经验包括从分子机制到 炎症性肠病、微生物和婴儿腹泻疾病中的钙/磷吸收与基因组学 Niemann-Pick C病和淋巴水肿-血管发育不良综合征的蛋白质组学；先天性心脏病 机制、并发症和管理；自闭症、残疾和康复；下一代多式联运 成像；儿科头部创伤和药物滥用的流行病学；产妇保健和性方面的实地工作 传播疾病。SCR涉及经验丰富、热情的教职员工和接近同行的导师，主要是在儿科，但 广泛代表影响NICHD任务区儿童的基础和临床研究。专门化的SCR 课程被纳入到一个创新的面对面和在线询问的医学暑期研究所 高中的无知(强调未回答的问题和未被质疑的答案，并强化核心内容) 学生和本科生，并与我们的医学生研究员提供的。包括具有高度互动性的 我们独特的虚拟临床研究中心/问卷室，这是一个旨在连接NIH的基于网络的平台， 使用青少年熟悉的先进多媒体技术，向K-12社区提供CTSA/GCR。同级和近级 指导和交流/生存/兴旺技能会议用于培养 富有成效、好奇和道德的科学家在职业道路上的协作团队中工作，与他们的 招聘教师。广泛的短期/长期形成性和终结性参与者和项目评估 记录SCR迄今的成功以及其多样化、弱势、主要是URM参与者的进展，这些参与者来自以下资源- 将继续开发可复制的模式和产品，以便在全国范围内向其他环境传播。

“Summers in Children's Research” (SCR) at The University of Arizona Health Sciences Center, Steele Children's Research Center, and Diamond Children's Medical Center offers annually in this 5-year renewal grant proposal 12 diverse disadvantaged junior/senior high school students and 5 continuing undergraduates from Arizona an immersive educational 8- and 12- week summer experience respectively in “hands on, brain on” basic, translational, and clinical research broadly targeting childhood and human development and associated disorders. The multidisciplinary project leadership duo includes an internationally renowned pediatrician specialized in children's gastrointestinal disorders (molecular mechanisms and clinical management) and an international expert in childhood and developmental lymphatic disorders and genotype-phenotype correlations, diversity pipeline research training, and inquiry curriculum innovation. They will together interact with vibrant research programs impacting children's and maternal health. Based on the College of Medicine's highly successful longstanding federally funded multidisciplinary disadvantaged multilevel student research programs and diversity/URM pipeline continuum drawing large numbers of qualified applicants from around Arizona and also a locally supported Dept. of Pediatrics high school student summer program, SCR for the past 5 years has been stepwise developing a distinctive core curriculum including online components and expanded research experiences in NICHD mission areas. Full-time summer research experiences range from molecular mechanisms of calcium/phosphate absorption in inflammatory bowel disease, microbiomics, and infant diarrheal disorders to genomics- proteomics of Niemann-Pick C disease and lymphedema-angiodysplasia syndromes; congenital heart disease – mechanisms, complications, and management; autism, disabilities and rehabilitation; next generation multimodal imaging; epidemiology of pediatric head trauma and substance abuse, and field work in maternal health and sexually transmitted diseases. SCR involves experienced, enthusiastic faculty and near-peer mentors primarily in Pediatrics but broadly representing basic and clinical research impacting children in NICHD mission areas. The specialized SCR curriculum is incorporated into an innovative face-to-face and online inquiry-based Summer Institute on Medical Ignorance (highlighting Unanswered Questions and Unquestioned Answers and reinforcing core content) for high school students and undergraduates and paralleling our medical student researcher offering. Included are highly interactive features such as our unique Virtual Clinical Research Center/Questionarium, a web-based platform designed to link NIH, CTSAs/GCRCs to the K-12 community, using advanced multimedia technology familiar to teenagers. Peer and near-peer mentoring and communication/surviving/thriving skill sessions are used to develop attitudes, skills, and behaviors of fruitful, curious, and ethical scientists working in collaborative teams along career pathways in concert with their recruiting teachers. Extensive short-term/long-term formative and summative participant and project evaluation documents SCR's success to date and the progress of its diverse, disadvantaged, largely URM participants from resource- poor schools and will be continued to develop replicable models and products to disseminate nationally to other settings.