Basic Cardiovascular Research Training Grant

尽管经过了几十年的研究，我们对潜在机制的认识仍然存在根本性的空白 导致大多数心血管（CV）疾病的发展和进展，以及终末期 这些疾病的临床后果以及如何更好地治疗或预防它们。T32的核心前提是 基础和转化心血管研究培训计划（CVTP）的特点是这些疾病极其 复杂，严格的研究要求学员有一个坚实的基础知识的基本 CV生理学、发育生物学、遗传学、基因组学、生物信息学、表观遗传学、病理学、系统 生物学、生物医学工程和其他学科。我们的CVTP的一个主要优势是，我们有40个 代表这些领域的杰出临床，转化和基础科学导师，并建立了独特的 过去几十年的培训计划，将指导人才融入到培养最优秀的培训人员中。 CV科学家可能。我们的目标是为博士前和博士后学员提供必要的知识， 智力能力，技术技能，激情和解决问题的能力，以进行杰出的国家， 最先进的简历研究采用了广泛的强大和创新的方法。请求支助8 博士前和7博士后研究员谁代表了一个更大的队列CVTP学员的一小部分， 都在导师实验室工作该项目由联合PI加里K博士领导。欧文斯和布兰特·伊萨克森也是 作为两位才华横溢的副导演Coleen McNamara博士和Shayn Peirce-Cottler博士，他们都是杰出的 CV研究人员和导师。博士预科学员最初是从大量优秀学员中挑选出来的 招募到伞生物医学科学（BIMS）研究生课程或UVA MD/PhD（NIH MST） 计划，而博士后候选人主要是由个别导师实验室或从几个之一招募 临床住院医师奖学金计划。在完成高度创新的BIMS 6000核心课程后， 在01年的生物学，CVTP博士预科学员选修模块化课程，这些课程是根据他们的 兴趣和学位课程。他们还完成三个实验室轮换，以帮助选择导师。只 已选择职业培训导师的学员可获委任为导师。所有学员都必须参加 我们的签名CVTP高级课程，包括BIMS 8052-3（高级血管生物学）和BIMS 8064（a 学员经营的职业/职业课程），并要求参加我们每周的研究研讨会， 每月一次的研究进展会议，一年两次的研究务虚会，并完成生物医学伦理培训。 CVTP也有一个特殊的赠款写作计划，包括年度研讨会和大约20 年度资助酝酿会议这一计划的成功有许多指标，包括：1）许多前 CVTG学员在各自领域的领导者; 2）目前CVTG学员发表了许多高影响力的第一作者 论文，并有48%的成功率，在确保校外奖学金在第一次提交;和3）90%的 过去10年完成培训的学员获得了高质量的长期研究职位。

Despite decades of research there are still fundamental gaps in our knowledge of the underlying mechanisms that contribute to development and progression of most cardiovascular (CV) diseases, as well as the end stage clinical consequences of these diseases and how to better treat or prevent them. A central premise of this T32 Basic and Translational Cardiovascular Research Training Program (CVTP) is that these diseases are extremely complex, and that rigorous study of them requires trainees to have a strong foundation of knowledge of basic CV physiology, developmental biology, genetics, genomics, bioinformatics, epigenetics, pathology, systems biology, biomedical engineering, and other disciplines. A major strength of our CVTP is that we have 40 outstanding clinical, translational, and basic science mentors representing these areas, and have built a unique training program over the past several decades that integrates mentoring talents into producing the best trained CV scientists possible. Our goal is to provide pre-doctoral and post-doctoral trainees the necessary knowledge, intellectual capabilities, technical skills, passion, and problem-solving abilities to conduct outstanding state-of- the-art CV research employing a wide range of powerful and innovative approaches. Support is requested for 8 pre- and 7 post-doctoral fellows who represent a small fraction of a much larger cohort of CVTP trainees who are working in mentor laboratories. The program is led by co-PIs Drs. Gary K. Owens and Brant Isakson, as well as two talented Associate Directors Drs. Coleen McNamara and Shayn Peirce-Cottler who are all exceptional CV researchers and mentors. Pre-doctoral trainees are selected from a large pool of outstanding trainees initially recruited into an umbrella biomedical sciences (BIMS) graduate program or the UVA MD/PhD (NIH MST) Program, whereas post-doctoral candidates are largely recruited by individual mentor labs or from one of several clinical residency-fellowship programs. After completing a highly innovative BIMS 6000 core course in integrated biology in year 01, CVTP pre-doctoral trainees take elective modular courses that are customized based on their interests and degree program. They also complete three lab rotations to aid in selection of a mentor. Only trainees who have already selected a CVTP mentor are eligible for appointment. All trainees are required to take our signature CVTP advanced courses including BIMS 8052-3 (Advanced Vascular Biology) and BIMS 8064 (a trainee-run Careers/Professionalism Course), and are also required to attend our weekly research seminars, monthly research in progress sessions, bi-annual research retreats, and to complete biomedical ethics training. The CVTP also has an exceptional grant writing program including an annual workshop and approximately 20 annual grant brewing sessions. There are many indices of the success of this program including: 1) many former CVTG trainees being leaders in their field; 2) current CVTG trainees publishing many high impact first author papers and having a 48% success rate in securing extramural fellowships upon first submission; and 3) 90% of trainees who have completed training the last 10 years have secured high quality permanent research positions.