BIOINFORMATICS

生物信息学核心综述 生物信息学核心是提供专业和及时的生物信息学的集中资源 为众多客户提供咨询、分析、协作研究、管理和培训解决方案 生物医学数据，包括高通量数据。生物信息学核心将支持 INBRE IV：夏威夷全州研究和教育伙伴关系(HiSREP)通过提供强大和综合的 生物信息学服务于研究、教育、调查和创新方法的创造。 在INBRE III期间，对生物信息学核心进行了重组，以更好地作为HiSREP的资源 因此，取得了实质性的进展。我们观察到每年都有增加的 使用几乎所有HiSREP机构的生物信息学核心服务的用户(近5倍)。这个 生物信息学核心成功地提供了生物信息学/生物统计学培训和教育机会 给HiSREP社区。在INBRE III期间，生物信息学基础设施也得到了显著加强。 具体地说，最近购买了一台Illumina NextSeq 500机器，它的功能将大大加快 HiSREP网络中基于下一代测序的研究。此外，Cray CS300 UH ITS中心安装了超级计算机，生物信息学核心完全可以访问该中心。 在INBRE IV中，生物信息学核心将继续作为网络的重要组成部分发挥作用。 具体地说，核心将以三种主要方式促进INBRE IV的目标：(1)定制服务： CORE将促进为赠款申请和随后的研究获得初步数据 HiSREP研究人员通过咨询实验设计和数据管理，并提供专业知识 生物信息学和生物统计学方面的数据分析和解释；(2)教育和培训： 生物信息学核心将提供生物信息学和生物统计学方面的教育，以及对职业生涯的支持 发展研究人员(包括学生和教职员工)；以及；(Iii)核心发展：生物信息学核心 将创造新的工具和方法或重新调整现有工具和战略的用途，以加快在 科学。在所有这些活动中，核心将与其他地方和国家生物信息学合作 核心。 为了实现这些目标，我们提出了四个具体目标：(1) 扩展生物信息学核心服务以 支持 HiSREP研究人员的生物医学研究需求 在他们的研究中表现出色。(2)提供 为所有阶段的HiSREP研究学生提供生物信息学相关主题的教育和培训机会 科学家以及社区合作伙伴。(3)开发新的生物信息学工具，提高生物信息学水平 通过生物信息学核心的组合和扩展的专业知识的相互作用进行研究。(4)建设 通过与HiSREP的互动和协作实现机构和社区研究的协同增效 合伙人。

BIOINFORMATICS CORE SUMMARY The Bioinformatics Core serves as a centralized resource for providing expert and timely bioinformatics consulting, analysis, collaborative research, management, and training solutions for a broad range of biomedical data including high-throughput data. The Bioinformatics Core will support the specific aims of the INBRE IV: Hawaii Statewide Research & Education Partnership (HiSREP) by providing a strong and integrated bioinformatics service in research, education, investigation and creation of innovative methodologies. During INBRE III, the Bioinformatics Core was reorganized to better serve as a resource to the HiSREP community, and consequently made substantial progress. We observed an annual increase in the number of users (nearly 5-fold) utilizing the Bioinformatics Core services from almost all the HiSREP institutions. The Bioinformatics Core has successfully provided bioinformatics/biostatistics training and education opportunities to the HiSREP community. During INBRE III, the Bioinformatics infrastructure was also significantly enhanced. Specifically, an Illumina NextSeq 500 machine was recently purchased and will function to greatly accelerate the next generation sequencing-based research in the HiSREP network. In addition, a Cray CS300 Supercomputer was installed at UH ITS Center, to which the Bioinformatics Core has full access. In INBRE IV, the Bioinformatics Core will continue to function as an important component of the network. Specifically, the Core will contribute to INBRE IV objectives in three key ways: (i) Customized Services: the core will facilitate the acquisition of preliminary data for grant applications and subsequent research by HiSREP investigators via consultation on experimental design and data management as well as offer expertise in data analysis and interpretation in bioinformatics and biostatistics; (ii) Education and Training: the Bioinformatics Core will provide education in bioinformatics and biostatistics, as well as support for the career development of researchers (both students and faculty), and; (iii) Core Development: the Bioinformatics Core will create new tools and methods or repurpose existing tools and strategies to accelerate advances in the science. In all of these activities, the Core will work collaboratively with other local and national bioinformatics cores. To reach these goals, we propose four Specific Aims: (1) Expand Bioinformatics Core services to support biomedical research needs of HiSREP investigators in the performance of their research. (2) Provide education and training opportunities in bioinformatics-related topics to all stage HiSREP research students and scientists as well as community partners. (3) Develop novel bioinformatics tools to enhance bioinformatics research through the interactions of the combined and expanded expertise of the Bioinformatics Core. (4) Build institutional and community research synergy through the interaction and collaboration with the HiSREP partners.