Developing of a computer-based multimodal mind and body approach for mild cognitive decline

摘要 轻度认知功能障碍(MCI)是介于正常衰老和老年痴呆诊断之间的中间状态。 临床上可能是极早期的阿尔茨海默病(AD)。由于MCI在AD发作之前就表现出来了，它可能是 阿尔茨海默病和老年性痴呆预防治疗的最佳干预阶段 进行性神经功能丧失和不可逆转的认知损害。尽管如此，药物治疗对 MCI远远不能令人满意，这突显了MCI迫切需要新的治疗方案。 八段锦是一种独特而创新的心身运动，其特点是对称性的相互作用 身体姿势和运动，重点是加强肌肉和肌腱。它由八个简单的 在视频/音频的指导下，可以在家中轻松练习的动作。这些特点使它 对于患有MCI的老年人来说是一个合适的选择。我们小组和其他人的研究都证明了它 改善老年MCI患者认知功能的潜力。然而，研究也表明， 对BDJ的反应差异很大，一些人只表现出适度的反应。要克服 挑战是，这个应用程序旨在将BDJ与其他身心方法相结合，以开发更多 MCI的有效治疗选择。 这一阶段R41(STTR)应用程序的目标是开发基于计算机的多模式身心 改善MCI认知功能的方法(CbMMBA)。具体地说，我们将首先开发一个功能 CbMMBA平台(原型)集BDJ、穴位按摩和放松技术于一体(目标1)。我们选择了 这些方法，不仅是因为这些方法中的一些方法本身就展示了它们改进的潜力 MCI/痴呆症的认知功能，但因为它们也可以相互积极互动产生 协同效应。接下来，我们将使用MCI上的cbMMBA(目标2)进行可行性研究。 这项应用如果成功，将为MCI和MCI提供一种经济高效且易于获得的治疗选择 其他与年龄相关的痴呆症，显著改善MCI的预防发展，并直接受益 患有这种高度流行的疾病的患者，特别是那些可能接触到- 人的心理和身体干预。

Summary Mild cognitive impairment (MCI) represents an intermediate state between normal aging and the diagnosis of clinically probable very early Alzheimer's disease (AD). Since MCI manifests before the onset of AD, it may be the optimal stage in which to intervene with preventative therapies for AD and age-related dementia before progressive neurological loss and irreversible cognitive impairment. Nevertheless, pharmacologic treatment for MCI is far from satisfactory, highlighting the urgent need for new treatment solutions for MCI. Baduanjin (BDJ) is a unique and innovative mind-body exercise characterized by the interplay of symmetrical physical postures and movements, focusing on strengthening muscles and tendons. It consists of eight simple movements that can be easily practiced at home when guided by videos /audio. These characteristics make it a suitable option for older adults with MCI. Studies from both our group and others have demonstrated its potentials for improving cognitive function for older adults with MCI. Nevertheless, studies also showed that the response to BDJ varies significantly, some individuals demonstrate only a moderate response. To overcome the challenge, this application aims to integrate BDJ with other mind and body approaches to develop a more effective treatment option for MCI. The goal of this Phase I R41 (STTR) application is to develop a computer-based multimodal mind and body approach (cbMMBA) to improve the cognitive function for MCI. Specifically, we will first develop a functional cbMMBA platform (prototype) integrating BDJ, acupressure, and relaxation techniques (Aim 1). We chose these methods, not only because some of these methods alone have demonstrated their potential to improve cognitive function in MCI / dementia, but because they also can interact with each other positively to produce synergistic effects. Next, we will perform a feasibility study using the cbMMBA on MCI (Aim 2). This application, if successful, will provide a cost-effective and easily accessible treatment option for MCI and other age-related dementia, significantly improve the prevention of MCI development, and directly benefit patients suffering from the highly prevalent disorder, particularly for those who may have limited access to in- person mind and body interventions.