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Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses

Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses
所有癌症诊断中口面裂风险变异的关联研究
批准号：
10654330
负责人：
Mary L. Marazita
金额：
$11.81万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
已结题
起止时间：
2022-08-15 至 2023-03-31
来源：
https://reporter.nih.gov/project-details/10654330
关键词：
AddressAdministrative SupplementBehavior TherapyChildCleft LipDataData SetDentalFaceGenesGeneticGenetic RiskGoalsGrantHumanIndividualInfant MortalityInterventionLifeLive BirthMalignant NeoplasmsMedicalNutritionalOperative Surgical ProceduresPalatePublic HealthRisk FactorsSpeechStructural Congenital AnomaliesTreatment CostVariantcancer diagnosiscancer riskcomorbiditydata harmonizationfeedinggenetic architecturehealth economicshigh riskmortalityorofacial cleftparent grantrisk variant

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中文摘要
翻译
摘要 这项新的补助金是对父补助金R03-DE032062的修订/行政补充。很早以前就有人注意到 患有口面部裂(OFCs)的人及其未受影响的亲属患某些疾病的风险较高 癌症。这项修订的假设是OFC与癌症之间的联系部分是由于 遗传上的共性。在这次修订中，我们将调查OFC遗传风险之间可能的关联 变种与我们所有人的癌症诊断。
英文摘要
ABSTRACT This new grant is a Revision/Administrative Supplement to parent grant R03-DE032062. It has long been noted that individuals with orofacial clefts (OFCs) and their unaffected relatives have a higher risk of certain cancers. The hypothesis of this revision is that the association between OFC and cancer is in part due to genetic commonalities. In this Revision, we will investigate possible associations between OFC genetic risk variants with the cancer diagnoses in All of Us.
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Genomic Risk Variants in Orofacial Clefting: Discovery and Functional Validation
Differences between the sexes among genetic variants affecting orofacial cleft birth defect risk
  • 批准号：
    10602447
  • 项目类别：
  • 资助金额：
    $40.7万
  • 财政年份：
    2022
  • 负责人：
    Mary L. Marazita
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Differences between the sexes among genetic variants affecting orofacial cleft birth defect risk
  • 批准号：
    10420286
  • 项目类别：
  • 资助金额：
    $41.55万
  • 财政年份：
    2022
  • 负责人：
    Mary L. Marazita
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Enhanced Data from Orofacial Cleft Trios to Strengthen the Gabriella Miller Kids First (GMKF) Discovery Goals
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