Applying Item Response Theory to Improve Patient Reported Outcome Use in Dermatology Clinical Practice

项目摘要/摘要 研究：虽然有效地衡量患者对他们的疾病及其治疗的看法提供了 免费提供客观疾病严重程度的信息，患者报告的结果捕捉到了活着的人 慢性炎症性皮肤病的经验很少在皮肤科的常规实践中使用。项目响应 理论技术可以在临床上更有效地管理患者报告的结果，这 可以解决实施这些措施的时间等障碍。这项研究的目的是：1.确定优先顺序 对患有慢性炎症性皮肤病的个人最有意义的结果域，如 痤疮、牛皮癣和特应性皮炎；2.评估一名新患者的内容有效性--报道的结果 测量信息系统(PROIS)配置文件测量这些领域；3.现场测试和评估 一个新的PROMIS档案的有效性，以捕捉慢性炎症性皮肤病的生活经验。这个 这项K23奖励计划的总体目标是改善慢性炎症性皮肤患者的护理 通过制定一个实际的患者报告的结果来衡量这些皮肤的生活体验 这将使常规临床护理中更多地使用患者报告的结果。 候选人：Barbieri博士的长期职业目标是成为一名独立的、以病人为中心的医生-- 科学家，重点关注慢性炎症性皮肤病、患者报告的结果和健康服务 研究。他之前的培训为他提供了这些领域的基础背景。 环境：在获奖期间，Barbieri博士将把80%的时间用于临床研究，20%的时间用于 痤疮、特应性皮炎等慢性炎症性皮肤病患者的临床护理 银屑病。马戈利斯博士和普西奇博士是候选人的主要导师，他们直接监督了 许多成功的初级教员和Barbieri博士将从他的经验和热情中受益 培养初级科学家的职业生涯。布里格姆妇女医院提供丰富的培训 环境，包括临床研究创新和试验股提供的资源和专门知识 (CUReIT)和患者报告的结果、价值和体验(Proven)中心。结合了 皮肤科、马戈利斯医生和普西奇医生的知识和专业知识 实验室，这些机会将提供一个无与伦比的机会开始作为内科科学家的职业生涯。 职业发展：在他的顾问委员会的支持下，Barbieri博士的培训将集中在 先进的心理测量技术和定性研究，建立了强大的尊重知识基础 到患者报告的结果开发和验证。完成拟议的研究和职业生涯 发展计划将给予Barbieri博士知识和技能，以实现科学独立、过渡 终身教职跟踪教师职位，并为以患者为导向的临床研究职业生涯奠定坚实的基础。

Project Summary/Abstract Research: While effective measurement of the patient’s perspective on their illness and its treatment provides complimentary information to objective disease severity, patient-reported outcomes capturing the lived experience of chronic inflammatory skin disease are rarely used in routine dermatology practice. Item response theory techniques can enable more efficient administration of patient-reported outcomes in the clinic, which can address barriers such as time to administer these measures. The purpose of this study is to 1. prioritize the outcome domains that are most meaningful to individuals with chronic inflammatory skin diseases such as acne, psoriasis, and atopic dermatitis; 2. evaluate the content validity of a novel Patient-Reported Outcomes Measurement Information System (PROMIS) profile measuring these domains; 3. field test and evaluate the validity of a novel PROMIS profile to capture the lived experience of chronic inflammatory skin disease. The overall objectives of this K23 award proposal are to improve the care of patients with chronic inflammatory skin diseases by developing a practical patient-reported outcome to measure the lived experience of these skin diseases, which will enable increased use of patient-reported outcomes in routine clinical care. Candidate: Dr. Barbieri’s long-term career goal is to become an independent, patient-oriented physician- scientist, with a focus on chronic inflammatory skin diseases, patient-reported outcomes, and health services research. His prior training has provided him with a foundational background in these areas. Environment: During the award period Dr. Barbieri will devote 80% of his time to clinical research and 20% to the clinical care of patients with chronic inflammatory skin disease such as acne, atopic dermatitis, and psoriasis. Dr. Margolis and Dr. Pusic, the candidate’s primary mentors, have directly supervised the training of numerous successful junior faculty members and Dr. Barbieri will benefit from his experience and enthusiasm for cultivating the careers of junior scientists. The Brigham and Women’s Hospital offers a rich training environment, including resources and expertise available in the Clinical Unit for Research Innovation and Trials (CUReIT) and Patient-Reported Outcomes, Value & Experience (PROVE) Center. Combined with the knowledge and expertise available in the Department of Dermatology and in Dr. Margolis’s and Dr. Pusic’s labs, these opportunities will provide an unparalleled opportunity to begin a career as a physician scientist. Career Development: With the support of his advisory committee, Dr. Barbieri’s training will focus on advanced psychometric techniques and qualitative research to develop a strong knowledge base with respect to patient-reported outcome development and validation. Completion of the proposed research and career development plan will give Dr. Barbieri the knowledge and skills to achieve scientific independence, transition to a tenure track faculty position, and build a strong foundation for a career in patient-oriented clinical research.