Boston Roybal Center for Active Lifestyle Interventions

项目摘要：试点核心B将支持波士顿Roybal 积极生活方式干预中心(RALI波士顿)将致力于开发和测试其总体目标 行为改变策略，增加体力活动，促进健康老龄化，特别是对 健康状况不佳的高风险。Pilot Core将通过支持一组创新的 以及由试点研究人员进行的科学严谨的临床试验，他们将增强我们的知识基础，开发 新的研究方法和工具，传播我们的成果，并最终合作 开发必要的试点数据和经验，以便在未来进行全面的翻译干预 临床试验。核心的具体目标是：1)征集、选择和支持两到三个最 每年提交给我们的有价值的试点研究，以开发和测试新的多组件策略，以 促进行为改变，促进科学进步，改善老年人的健康和福祉 人员；2)监督和支持试点调查员及其项目的进展，并提供资源 确保他们成功地测试行为干预的可行性、可接受性和有效性 NIH阶段模式；3)将试点项目的研究成果应用于设计翻译项目和 与调查人员合作，寻求额外的资金，在NIH阶段的不同阶段开发和测试它们 模式；4)执行程序，以确保我们的研究和研究的科学完整性、严谨性和重复性 人类受试者的安全。Pilot核心领导者(Margie Lachman博士、Lewis Lipsitz博士和Theresa Ellis博士) 将与管理和行政核心密切合作，以确保中心顺利运行和 实现了它的目标。制定了征集、审查和支持新的试点项目的程序。试点项目将 利用最有希望的最新证据，将心理社会、行为、认知和神经科学联系起来 影响健康的因素，并探索参与动机和行为改变的机制。两项试验性研究是 建议在本次续展申请的初期检查增强双方动机的效果 和执行控制，这两个过程在产生更多的体力活动方面显示出希望 久坐不动的人。一项试验是一项随机对照试验，将测试10- 单次经颅直流电刺激对左侧额叶背外侧前部的干预 大脑皮质对无明显身体活动的老年人坚持个性化体力活动目标的影响 疾病或疾病。第二个试点将考察两个心理社会因素的影响，即积极的信息 以及自我肯定，关于激励和参与体育活动，以及随着时间的推移保持这些活动， 相比之下，控制组只收到积极的消息。这些研究的结果将用于 开发新的干预措施，用于在更大规模的临床试验中进行测试。试点核心将继续监督 开发新的试点研究并翻译和传播中心的研究结果。

Project Summary: The Pilot Core B will support one of the principle mechanisms by which the Boston Roybal Center for Active Lifestyle Interventions (RALI Boston) will address its overarching goal to develop and test behavior change strategies that increase physical activity and promote healthy aging, especially for persons at high risk for poor health outcomes. The Pilot Core will achieve this goal by supporting a group of innovative and scientifically rigorous clinical trials by pilot investigators who will enhance our knowledge base, develop novel research methodologies and tools, disseminate our results, and ultimately work collaboratively to develop the pilot data and experience necessary to conduct future full-scale translational interventions using clinical trials. The specific aims of the Core are: 1) to solicit, select, and support two to three of the most meritorious pilot studies submitted to us each year to develop and test novel multicomponent strategies to promote behavioral changes that advance the science and result in improved health and well-being for older people; 2) to oversee and support the progress of pilot investigators and their projects and provide resources to assure their success in testing the feasibility, acceptability and efficacy of behavioral interventions guided by the NIH Stage Model; 3) to apply the research findings from the pilot projects to design translational projects and work with investigators to seek additional funding to develop and test them at different phases of the NIH Stage Model; 4) to implement procedures to assure the scientific integrity, rigor and reproducibility of our research and the safety of human subjects. The Pilot Core Leaders (Drs. Margie Lachman, Lewis Lipsitz and Theresa Ellis) will work closely with the Management and Administrative Core to ensure the Center operates smoothly and fulfills its aims. Procedures are in place to solicit, review and support new pilot projects. The pilot projects will draw on the most promising recent evidence linking psychosocial, behavioral, cognitive, and neuroscientific factors to health and to explore mechanisms involved in motivation and behavior change. Two pilot studies are proposed for the initial period of this renewal application to examine the efficacy of enhancing both motivation and executive control, two processes that have shown promise in engendering increased physical activity in sedentary individuals. One pilot is a randomized controlled trial that will test the feasibility and effects of a 10- session transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on adherence to a personalized physical activity goal in physically-inactive older adults without overt illness or disease. The second pilot will examine the effects of two psychosocial factors, positive messaging and self-affirmation, on motivation and engagement in physical activity and their maintenance over time, compared to a control group that receives only positive messaging. Results of these studies will be used to develop new interventions for testing in larger scale clinical trials. The pilot core will continue to oversee the development of novel pilot studies and the translation and dissemination of findings from the Center.