Boston Roybal Center for Active Lifestyle Interventions

波士顿罗伊巴尔积极生活方式干预中心(RALI波士顿)的总体目标是发展和 测试行为改变策略以促进健康老龄化，特别是在久坐的成年人和其他 健康状况不佳的高风险。众所周知，体育锻炼对身体健康大有裨益， 心理和认知方面的健康。然而，中老年人的数量 经常性的活跃度仍然相当低。这份Rali Boston续约申请重点关注RFA的主题#2： “促进体力活动，创建、修改和试行以测试原则为基础的干预措施，以减少久坐 行为和增加体力活动。该项目的具体目标是：1)进行创新的临床 基于确凿的研究证据和使用NIH阶段模型的试验，可以转化为增加 中老年人的体育锻炼是健康老龄化的一种手段，2)促进 干预研究中的行为改变过程，通过识别和测试导致 增加体力活动，改善健康和福祉，3)提供必要的科学专门知识 和资源，通过领导和协调，促进创新的跨学科研究和翻译 五所大学和社区组织的项目。这些目标将通过两个途径实现 核心、管理和行政核心和试点核心。我们将开发新的行为改变 策略，评估它们在不同脆弱人群的临床试验中的工作情况，并评估 它们导致了体力活动的持续变化，使用了经过充分验证的措施，可以用来 我们Rali工具箱中的调查人员。最终，我们将使用获得的信息来改进技术和 更新我们的概念框架，并将开发和测试旨在 改善中老年人的活动、健康和生活质量。该中心的特点是 许多创新特征：它1)识别对人类行为的多重影响，这些影响在 复杂的方式和应用独特的多组件行为改变模型；2)使用个性化的 根据个人特点和具体情况调整建议的干预措施 3)扩展了我们的重点，包括基本的神经机制和其他媒介 通过使用新的成像方法和非侵入性电刺激来改变行为；4)专注于 服务不足、易受伤害的中老年人群面临健康状况不佳和 与社区组织合作，服务于各种中老年人，他们将受益于 以活动为中心；5)使用行为测量的共同核心，使我们能够比较 不同的试点研究干预措施；6)成功地聘请了一支忠诚的、跨学科的高级团队 调查人员带来了来自五所大学的多个专业视角和广泛的资源： Brandeis U，波士顿大学，波士顿学院，东北大学，哈佛医学院/希伯来老年生活。

The overall goal of the Boston Roybal Center for Active Lifestyle Interventions (RALI Boston) is to develop and test behavior change strategies to promote healthy aging, especially among sedentary adults and others at high risk for poor health outcomes. It is widely known that physical activity is broadly beneficial for physical, psychological, and cognitive aspects of health. However, the number of middle-aged and older adults who are regularly active remains quite low. This RALI Boston renewal application focuses on theme #2 from the RFA: “Physical activity promotion to create, modify and pilot test principle-based interventions to reduce sedentary behavior and increase physical activity.” The specific aims of the project are to: 1) conduct innovative clinical trials based on solid research evidence and using the NIH Stage Model that can be translated to increase physical activity in middle-aged and older adults as a means to healthy aging, 2) advance research on behavior change processes in intervention research by identifying and testing the mechanisms that lead to increases in physical activity and improved health and well-being, 3) provide the necessary scientific expertise and resources to facilitate innovative interdisciplinary research and translation by leading and coordinating projects across five universities and community organizations. These aims will be accomplished through two cores, the Management and Administration Core and the Pilot Core. We will develop novel behavior change strategies, evaluate how they work in clinical trials with different vulnerable populations, and assess whether they lead to sustained changes in physical activity, using well-validated measures that are available to investigators in our RALI Toolbox. Ultimately, we will use the information gained to refine the techniques and update our conceptual framework, and will develop and test full scale translational interventions designed to improve activity, health and quality of life among middle-aged and older adults. The Center is distinguished by a number of innovative features: It 1) recognizes the multiple influences on human behavior that interact in complex ways and applies a unique multi-component model of behavior change; 2) uses a personalized approach and adapts the proposed interventions according to the individual characteristics and contextual circumstances of the person; 3) expands our focus to include basic neural mechanisms and other mediators of behavior change by employing novel imaging methods and noninvasive electrical stimulation; 4) focuses on underserved, vulnerable populations of middle-aged and elderly adults at risk for poor health outcomes and partners with community organizations serving diverse middle-aged and older adults who will benefit from the Center activities; 5) uses a common core of behavioral measures that will enable us to compare results of different pilot study interventions; 6) has successfully engaged a committed, interdisciplinary team of senior investigators who bring multiple professional perspectives and extensive resources from five universities: Brandeis U, Boston U., Boston College, Northeastern U., Harvard Medical School/Hebrew Senior Life.