Mentorship in Clinical Complementary and Integrative Health Research

因为在美国超过50%的成年人采取补充和综合健康（CIH）自然 产品为他们的健康，培训CIH从业人员和科学家，以产生高质量的临床研究 必须确定有效的产品，以保障公众的安全。因此，该提案要求K24 中期职业发展奖，以扩大和支持导师在临床天然产品研究博士。 瑞安布拉德利，ND，公共卫生硕士。布拉德利博士已经证明了有效的指导出版的所有过去 学员，以及多名学员从研究生到正式NIH博士后培训的进展 奖励和独立培训奖。布拉德利博士目前是NCCIH的项目总监和导师- 资助的T90/R90跨学科差距建筑研究（BRIDG）临床研究培训计划 由华盛顿大学（UW）和国立自然科学大学（National University of Natural Science）合作成立。 医学（NUNM）。布拉德利博士为10名博士后学员提供指导，包括CIH临床医生和 博士科学家。布拉德利博士是一名T90学员的主要导师，该学员已在 华盛顿大学，一个CIH医生谁收到了NICCH行政补充，以获得研究经验的博士。 布拉德利的R01资助的临床试验，以及俄勒冈州ORCCAMIND T32项目的T32博士后实习生 健康与科学大学（布拉德利博士是该大学的正式导师）。除了担任主任之外， 研究，高级研究员和副教授在NUNM，他保留附属和兼职 在3个美国和2个国际大学的任命，因此博士布拉德利是非常好的连接到 协助学员为他们的研究寻找资源和合作者。本提案的具体目标 布拉德利博士：1.在T32，T90，R90和T32中， KL2计划，以促进他们在研究培训和独立研究方面的进展（目标1）; 2。 通过在以下方面进行额外培训来完善和发展辅导技能：辅导;多样性，公平和包容 研究;和尖端的转化科学方法（目标2）;和3。提供暴露于 转化科学方法，并通过收集 与最近专门的促消退素介质（SPM）的临床试验相关的其他初步数据， 黄腐酚天然产品，包括产品质量评估， 储存的生物样本，以及测量额外的转录因子（PCSK 9），以将研究扩展到 新的临床人群（目标3）。

Because over 50% of adults in the United States take complementary and integrative health (CIH) natural products for their health, the training of CIH practitioners and scientists to produce high-quality clinical research is imperative to identifying effective products for the safety of the public. As such, this proposal requests a K24 mid-career development award to expand and support mentorship in clinical natural product research by Dr. Ryan Bradley, ND, MPH. Dr. Bradley has demonstrated effective mentorship by the publication of all past mentees, and the progression of multiple mentees from graduate students to formal NIH post-doctoral training awards, and independent training awards. Dr. Bradley is currently a Program Director and mentor in the NCCIH- funded T90/R90 Building Research across Interdisciplinary Gaps (BRIDG) clinical research training program formed in partnership between the University of Washington (UW) and the National University of Natural Medicine (NUNM). Dr. Bradley provides mentorship for 10 post-doctoral trainees, including CIH clinicians and PhD scientists. Dr. Bradley is a primary mentor for a T90 trainee who has progressed onto a KL2 award at the UW, a CIH practitioner who received a NICCH administrative supplement to gain research experience on Dr. Bradley's R01-funded clinical trials, and a T32 post-doctoral trainee in the ORCCAMIND T32 program at Oregon Health & Sciences University (for which Dr. Bradley is a formal mentor). In addition to his positions as Director of Research, Senior Investigator and Associate Professor at the NUNM, he retains affiliate and adjunct appointments at 3 US-based and 2 international universities, thus Dr. Bradley is extremely well connected to assist mentees in identifying resources and collaborators for their research. The Specific Aims of this proposal are for Dr. Bradley to: 1. Dedicate consistent effort in the mentorship of promising trainees in T32, T90, R90, and KL2 programs in order to facilitate their progression in research training and independent research (Aim 1); 2. Refine and develop mentoring skills by pursuing additional training in: mentorship; diversity, equity and inclusion in research; and cutting-edge translational science methodologies (Aim 2); and 3. Provide exposure to translational science methods and provide publication opportunities for mentees through the collection of additional preliminary data related to recent clinical trials of specialized pro-resolvin mediators (SPM) and xanthohumol natural products, including product quality assessment, measurement of relevant biomarkers in stored biologic samples, and measurement of additional transcription factors (PCSK9) to extend the research to new clinical populations (Aim 3).