Admin-Core-001

行政、指导和教育核心A：摘要 密西西比州围产期研究卓越中心科布雷基金第二阶段的主要目标 (MS CEPR)是为了促进一个创新的、国家认可的卓越中心的可持续性 从不良妊娠到母亲随后的健康结局的围产期研究 以及后代。更具体地说，围产期研究包括对发生在围产期的疾病状态的研究。 妊娠和出生后早期发育，导致母亲和 他们的后代跨越了他们的一生。研究的重点是综合关系和健康差距 不良妊娠、妊娠结局和心血管、肾脏、 代谢性和行为性疾病。这是一个重要的研究领域，特别是考虑到 不良胎儿环境带来的长期健康后果的证据，以及随后的低 出生体重。不良的围产期环境被认为至少在一定程度上导致了 肥胖、心血管、肾脏和行为疾病，对男性和女性后代来说，以及 使母亲更容易随着年龄的增长而增加这些疾病的风险。这对于以下方面尤其重要 密西西比州是先兆子痫、低出生体重、早产、肥胖、 美国的心血管、肾脏和代谢疾病以及高血压。COVID19的增加及其相关的并发症进一步增加了#年的发病率和死亡率 包括我们的高加索人和非裔美国人。因此，这个科布雷的第二阶段将继续改善 通过为以下方面提供基础设施和能力，实现MS CEPR的可持续性和研究卓越 建立一个由基础、临床和人口科学家组成的多学科、多样化的团队，致力于共同的 关于围产期疾病和健康差距的协同主题，并促进它们的合作。特定的 行政、指导和教育核心A的目标是为MS的所有方面提供领导 CEPR；协调和支持所有与中心相关的活动；维护和改进指导和 MS CEPR研究项目负责人(RPL)或试点项目负责人(PPL)的教育计划；接口 与NIGMS一起，密西西比大学医学中心(UMMC)管理部门，密西西比大学医学中心办公室 研究和赞助项目，包括获奖前和获奖后中心，代表的部门 招募、培训和指导不同群体的研究生和博士后研究员 提供下一代围产期研究人员，并为RPLs和PPLs提供指导经验 视需要组织联网会议和研讨会以及执行委员会会议， 内部和外部咨询委员会；并增加UMMC的调查人员人数，他们专注于 通过与科室主任合作聘请新的围产期调查人员进行围产期研究。

ADMINISTRATIVE, MENTORING AND EDUCATION CORE A: SUMMARY The major goal of Phase 2 of COBRE funding of the Mississippi Center of Excellence in Perinatal Research (MS CEPR) is to further the sustainability of an innovative, nationally recognized center of excellence in perinatal research spanning the spectrum from adverse pregnancy to subsequent health outcomes in mothers and offspring. More specifically, perinatal research encompasses the study of disease states that occur during gestation and early post-natal development that result in long-term adverse consequences in the mother and offspring across their lifespans. Research focuses on the integrative relationships and health disparities in adverse pregnancy, pregnancy outcomes, and developmental programming of cardiovascular, renal, metabolic and behavioral diseases. This is an important area for research especially in light of the increasing evidence of long term health consequences brought about by adverse fetal environment, and subsequent low birth weight. An adverse perinatal environment is thought to account at least in part for the development of obesity, cardiovascular, renal, and behavioral diseases later in life for male and female offspring, and predispose the mothers for increased risk of these diseases with aging. This is especially important for Mississippi since we have one of the highest rates of preeclampsia, low birth weight, preterm labor, obesity, cardiovascular, renal and metabolic diseases and hypertension in the United States. The addition of COVID19 and the complications associated with it further add to disproportionate levels of morbidity and mortality in both our Caucasian and African American populations. Thus, Phase 2 of this COBRE will continue to improve sustainability and research excellence in the MS CEPR by providing infrastructure and capacity for continued building of a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal diseases and health disparities and to facilitate their collaborations. Specific Aims of the Administrative, Mentoring and Education Core A are to provide leadership for all aspects of the MS CEPR; coordinate and provide support for all Center-related activities; maintain and improve mentoring and education programs for MS CEPR research project leaders (RPLs) or pilot project leaders (PPLs); interface with the NIGMS, the University of Mississippi Medical Center (UMMC) administration, the UMMC Office of Research and Sponsored Programs including Pre- and Post-Award Centers, the departments represented by RPLs and PPLs; recruit, train, and mentor a diverse group of graduate students and postdoctoral fellows to provide the next generation of perinatal researchers and to provide mentoring experience for RPLs and PPLs as needed; organize networking meetings and seminars as well as meetings of the Executive Committee, Internal and External Advisory Committees; and increase the number of investigators at UMMC who focus on perinatal research by working with department chairs to hire new perinatal investigators.