Alzheimer's Disease Research Center at Columbia Univ.

哥伦比亚的ADRC致力于促进和传播有关病因、预防和治疗的知识 阿尔茨海默氏症和其他与年龄相关的神经退行性和痴呆疾病。为此， 我们维护和跟踪正常老年人和老年人的多民族和多种族患者群体 认知障碍，以确定疾病的自然病史作为年龄和遗传的函数 化妆。在这个应用中，我们建议使用各种神经心理学、神经学和影像学方法 检查AD早期阶段的工具，并在他们的一生中跟踪这些受试者。在死亡的时候 将进行全面的神经病理检查，临床、放射学和病理学检查 对这种疾病的看法是相互关联的。从这些受试者身上获得的组织和DNA将用于研究 关于这种疾病的生物学和遗传学。亚洲发展研究中心内部的个人研究项目将审查 阿尔茨海默病的细胞和分子生物学的各个方面以及对脑功能的深入分析 在使用核磁共振的人类受试者身上。参加ADRC的患者将有机会参与试验 治疗痴呆症的新药和治疗方法的最新进展。有据可查的 这些患者的认知状况使他们非常适合纳入临床试验。教育和 哥伦比亚ADRC的信息核心致力于教育非专业人士和医学界有关AD的知识， 关于研究的最新进展和关于AD患者的护理。亚洲发展研究中心是 哥伦比亚大学内外的科学家，通过授予Pilot奖鼓励新的研究途径 赠款，通过提供组织和其他生物样本，通过提供获得仔细记录的 患者群体以及众多研讨会和临床病理相关会议。这个 遗传学核心是ADRC和ADRC家庭招募和识别的主要组织者 ADC。ADRC提供符合HIPAA标准的数据组织和统计咨询服务 哥伦比亚大学及其外部的研究界。

The ADRC at Columbia seeks to advance and disseminate knowledge of the causes, prevention and treatment of Alzheimer's Disease and other age-related neurodegenerative and dementing disorders. Toward this end, we maintain and follow a multi-ethnic and multi-racial patient population of normal elderly and the elderly with cognitive disorders to establish the natural history of the disease as a function of age and of genetic makeup. In this application we propose to use a variety of neuropsychological, neurological and imaging tools to examine the earliest stages of AD and to follow these subjects throughout their lives. At death a comprehensive neuropathologic examinationwill be performed and the clinical, radiological and pathological views of the disease correlated. Tissues and DNA obtained from these subjects will be available for research on the biology and genetics of the disease. Individualresearch projects within the ADRC will examine various aspects of the cellular and molecular biology of AD as well as an in-depth analysis of brain function in human subjects using MRI. Patients enrolled in the ADRC will have the opportunity to participate in trials of new drugs and treatments for dementing diseases as they become available. The well-documented cognitive status of these patients make them highly suitable for inclusion in clinical trials. The Educationand Information Core of the Columbia ADRC endeavors to educate both lay and medical communities about AD, about the latest advances in research and about the care of the AD patient. The ADRC serves as a resource for scientists with Columbia as well as outside of it, encouraging new research avenues by the award of pilot grants, by providing tissues and other biological samples, by providing access to a carefully documented patient population and by numerous seminars and Clinical Pathological Correlation Conferences. The Genetics Core serves as the major organizer of family recruitment and identification across the ADRCs and ADCs. HIPAA compliant data organization and statistical consulting services are provided under the ADRC to the research community at Columbia and external to it.