Interdisciplinary Training in Transplantation Biology

项目总结/摘要 迫切需要提高对移植排斥和耐受机制基础的理解， 将进步转化为临床，为尖端的基础和转化提供了令人兴奋的机会。 科学家迫切需要培训方案，以最佳方式培养下一代 移植研究者在强大的机构支持下，匹兹堡大学医学院 （UPSOM）Starzl移植研究所（STI）提供了一个独特的学术环境， 转化型的研究基础和文化，有利于培养强而全面、基础广泛的青年人才 移植生物学的基础科学家和医生。我们成熟和成熟的跨学科培训 移植生物学（TPTB）计划是非常清楚地从其他（成功的）培训计划划定 在UPSOM。我们的培训计划有助于确保训练有素的调查人员， 移植，可在学术界，工业界和政府附属机构担任领导角色 research.我们的高成就和资金充足的参与教师，进一步加强，因为我们的最后一次 研究领导人员的更新申请，特别是在骨髓和肺移植方面， 在富有成效的合作和对培训年轻调查人员的坚定承诺方面有着非常成功的记录。 专长包括免疫遗传学、缺血再灌注损伤、抗原呈递细胞、T和B细胞生物学， 干细胞生物学，耐受诱导，肝脏免疫学，移植感染性疾病，慢性排斥，同种异体， 以及异种识别、异种移植和人类移植免疫学。我们培训的独特之处 该计划是，调查范围从那些在无脊椎动物（教练的赠款是专家在无脊椎动物， 同种识别）和啮齿动物对非人灵长类和人的识别。在三个资助周期中，我们的学员 非常成功，在领先的期刊上发表文章，并获得个人研究奖学金，认可 以及职业发展奖和教职员职位。我们的目标是产生杰出的，潜在的 独立的研究者，非常熟悉移植中的基本和翻译问题 生物学和配备适当的调查，生存和职业发展技能。博士前 学员是从微生物学和免疫学课程的研究生中挑选出来的， UPSOM的跨学科生物医学研究生培训计划，包括医学科学家 培训计划，谁寻求在移植生物学博士学位。根据三年来取得的成就， 鉴于此培训补助金的前几个资助期以及合格申请人的可用性，我们请求支持 在16年及以后的几年中，有2名博士前实习生。具有MD、PhD或双学位的博士后培训生 将根据他们的杰出潜力进行选择，并支持2年。请求支助2 16年及以后的博士后实习生。我们的培训教师坚定地致力于确保 任命代表性不足的多样性群体的成员领取补助金。

PROJECT SUMMARY/ABSTRACT The pressing need to improve understanding of the mechanistic basis of transplant rejection and tolerance and to translate advances to the clinic, provides exciting opportunities for cutting-edge basic and translational scientists. There is a critical need for training programs that optimally prepare the next generation of transplantation researchers. With strong institutional support, the University of Pittsburgh School of Medicine (UPSOM) Starzl Transplantation Institute (STI) provides a unique academic environment, with an outstanding translational research base and culture, conducive to strong and comprehensive, broad-based training of young basic scientists and physicians in transplantation biology. Our established and proven Interdisciplinary Training Program in Transplantation Biology (TPTB) is very clearly delineated from other (successful) training programs at UPSOM. Our training program helps ensure that highly-trained investigators, strongly focused on transplantation, are available to assume leadership roles in academia, industry and government-affiliated research. Our highly-accomplished and well-funded participating faculty, further strengthened since our last renewal application by research leadership recruits, particularly in bone marrow and lung transplantation, have a very successful record of productive collaboration and strong commitment to training of young investigators. Expertise includes immunogenetics, ischemia-reperfusion injury, antigen-presenting cell, T and B cell biology, stem cell biology, tolerance induction, liver immunology, transplant infectious disease, chronic rejection, allo- and xenorecognition, xenotransplantation and human transplant immunology. A unique feature of our Training Program is that investigations range from those in invertebrates (a trainer on the grant is expert in invertebrate allorecognition) and rodents to non-human primates and humans. Over three funding cycles our trainees have been very successful, publishing in leading journals, and in obtaining individual research fellowships, recognition and career development awards and faculty positions. Our goal is to produce outstanding, potentially independent investigators, highly conversant with fundamental and translational questions in transplantation biology and equipped with appropriate investigational, survival and career development skills. Pre-doctoral trainees are selected from graduate students enrolled in the Program in Microbiology & Immunology and the Interdisciplinary Biomedical Graduate Training Program at UPSOM, including those in the medical scientist training program, who seek a PhD in transplantation biology. Based on successes achieved during the three previous funding periods of this Training Grant and the availability of well-qualified applicants, we request support of 2 pre-doctoral trainees in year 16 and subsequent years. Postdoctoral trainees with MD, PhD, or dual degrees will be selected based on their outstanding potential and supported for 2 years. Support is requested for 2 postdoctoral trainees in year 16 and subsequent years. Our training faculty are strongly committed to ensuring appointments of members of underrepresented diversity groups to the grant.