Feasibility of early detection of infection and sepsis in the home

项目摘要 脓毒症是感染的全身性表现，会导致复杂而昂贵的住院治疗，令人无法接受 高发病率和高死亡率。大多数研究集中在医院内脓毒症的检测；然而，大多数 败血症是社区获得性的，因此开始于家庭。南丁格尔实验室已经开发出一种全自动的 非接触式家庭床传感平台，无需任何患者即可检测住院签名 参与。在这里，我们将测试该技术是否可以用于检测感染或败血症。这款SBIR 建议书将评估可行性(第一阶段)并执行(第二阶段)前瞻性观察性研究以了解 因局部或系统感染即将住院的签名。这项工作将大大扩展 促进早期识别和干预以减少感染和败血症相关发病率的工具包 和死亡率。

PROJECT ABSTRACT Sepsis, the systemic manifestation of infection, causes complex and costly hospitalizations with unacceptably high morbidity and mortality. Most research focuses on detection of the sepsis within the hospital; however, most sepsis is community-acquired and thus begins in the home. Nightingale Labs has developed a fully automated non-contact home bed sensing platform that detects signatures of hospitalizations without requiring any patient participation. Here, we will test whether the technology can be used to detect infections or sepsis. This SBIR proposal will evaluate the feasibility (Phase 1) and execute (Phase 2) a prospective observational study to learn the signatures of impending hospitalizations for localized or systemic infection. The work will substantially expand the toolkit for facilitating early recognition and intervention to reduce infection- and sepsis-associated morbidity and mortality.