Administrative Core

总结 我们的腺瘤转化和基础科学中心（TBAC）的行政核心将服务于 优化和整合项目实验室之间以及项目实验室之间的调查流程 和核心们一起行政核心将提供后勤支持，加强沟通，促进数据 传播和建立一个系统，由项目执行机构对项目进行结构化监督。行政核心 还将提供行政支持，以促进其他TBEL之间的合作和沟通 中心，协调和数据管理中心（CDMC）; NCI工作人员，协作工业和 学术合作伙伴和合作的NCI计划（例如CISNET，NIST等）。行政核心将 为TBAC、TBEL社区成员提供指导并加强沟通， 外部合作伙伴 TBAC由项目实验室的三个调查小组组成：项目1（Grady，Yu，Maroni- Rana、Dai、Carter）、项目2（Halberg、Spengler、Snow、Newton）和项目3（Dey、莫雷拉、LaChance），以及 转化病理学和数据分析核心（Matkowskyj，Pickhardt，Sun，Kendziorski，Dinh），将 通过行政核心的协调，作为一个无缝的单位发挥作用。TBAC将密切互动 与其他TBEL中心和CDMC在其核心使命，以阐明翻译和早期生物学的 腺瘤TBAC还将根据需要与工业合作伙伴和学术合作伙伴合作， 推进项目研究。TBAC、其他TBEL中心、TBEL CDMC、行业合作伙伴和学术机构 合作伙伴将在本提案的研究以及由此产生的任何衍生研究方面进行合作 从TBAC的高度创新，生产力和调查的基本和重要的计划， 腺瘤的翻译生物学 行政核心有以下具体宗旨/目标： 具体目标1：提供支持TBAC关键目标的组织结构 具体目标2：提高大规模合作研究工作的管理效率， 多个机构和多个PD/PI 具体目标3：与TBEL CDMC和TBEL社区协议开发协调， 生物标本共享、生物标本设盲、数据分析、数据共享、数据协调、数据保存， 填充任何数据公共区，以及TBAC操作所需的任何其他相关功能 至于更大的TBL社区。

SUMMARY The Administrative Core of our Translational and Basic Science of Adenomas Center (TBAC) will serve to optimize and integrate the investigative processes of the Project Labs between each other and the Project Labs with the Cores. The Administrative Core will provide logistical support, enhance communication, facilitate data dissemination and create a system for structured oversight of the projects by the PIs. The Administrative Core will also provide administrative support to facilitate collaborations and communications between the other TBEL Centers, the Coordinating and Data Management Center (CDMC); NCI staff, collaborating industrial and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). The Administrative Core will provide guidance and enhance communication for and between the TBAC, TBEL Community members and external partners. The TBAC is comprised of three teams of investigators in the Project Labs: Project 1 (Grady, Yu, Maroni- Rana, Dai, Carter), Project 2 (Halberg, Spengler, Snow, Newton), and Project 3 (Dey, Morella, LaChance) and the Translational Pathology and Data Analysis Core (Matkowskyj, Pickhardt, Sun, Kendziorski, Dinh), who will function as a seamless unit though the coordination of the Administrative Core. The TBAC will interact closely with other TBEL Centers and the CDMC in its core mission to elucidate the translational and early biology of adenomas. The TBAC will also have collaborations with industrial partners and academic partners as needed to advance the Projects’ studies. The TBAC, other TBEL Centers, TBEL CDMC, industrial partners, and academic partners will collaborate on the studies in this proposal as well as on any resulting derivative studies that arise from the TBAC’s highly innovative, productive and significant program of investigation of the basic and translational biology of adenomas. The Administrative Core has the following Specific Aims/Goals: Specific Aim 1: To provide the organizational structure for supporting the key objectives of the TBAC Specific Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs Specific Aim 3: To coordinate with the TBEL CDMC and the TBEL community protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data harmonization, data deposition, populating any data commons, and any other relevant functions deemed necessary for TBAC operations as well as for the larger TBEL community.