Core A: Administrative Core

核心A：行政核心 摘要 行政核心旨在协调和支持本计划的所有活动。它 将积极主动地确保研究项目和核心之间的完全集成 围绕“整合基因组学”这一主题，这是该计划的重点。核心将是 负责监督本项目的日常活动，并确保总体上 该计划的目标已经实现。在其他活动中，本核心将组织两周一次 整个研究团队的会议，协调科学研讨会和研讨会，并举行 一年一度的静修。我们已经组建了一个由专家组成的外部咨询委员会(EAC) 在统计遗传学、癌症遗传流行病学、综合基因组学、 生物信息学和高性能计算。我们还召集了一份内部咨询 委员会(IAC)利用我们在这些相同学科的同事的深厚专业知识 在南加州大学。该核心将协调选管会的年度会议和 IAC，并将在全年促进与EAC或IAC成员的额外互动 视需要而定。核心将协调差旅、采购用品、监测预算、处理 处理人事问题，提交年度进展报告，并协助征聘新的调查员， 博士后和学生。 作为这一核心的联席主管，高德曼博士和西格蒙德博士将共同承担 项目的所有组织和财务活动。此外，高德曼博士会假设 项目活动的具体领导和西格蒙德博士对核心活动的具体领导。 这些特定于项目和核心的角色将保证 该计划得到了充分的管理。他们还将建立所需的基础设施 以实现跨项目和核心的有效沟通和协作。他们将共同担任主席 我们的IAC和计划举行一次EAC年度会议以及一次单独的年度科学务虚会 所有的项目和核心调查人员。利用他们作为该司司长的经验 生物统计学(Gauderman博士)和我们的生物统计学和流行病学教育主任 计划(西格蒙德博士)，他们将确保这一计划的雄心勃勃的目标 协调和支持。

Core A: Administrative Core Abstract The administrative core is designed to coordinate and support all the activities of this Program. It will work pro-actively to assure complete integrations across the Research Projects and Cores around the theme of “integrative genomics” that is the focus of the program. The Core will be responsible for overseeing the day-to-day activities of this program and assuring that the overall goals of the program are achieved. Among other activities, this Core will organize biweekly meetings of the entire research team, coordinate scientific seminars and workshops, and hold an annual retreat. We have assembled an External Advisory Committee (EAC) comprising experts from outside USC in statistical genetics, cancer genetic epidemiology, integrative genomics, bioinformatics, and high-performance computing. We have also assembled an Internal Advisory Committee (IAC) drawing on the deep expertise of our colleagues across these same disciplines within USC. The Core will coordinate an annual meeting of the EAC and quarterly meetings of the IAC, and it will facilitate additional interactions with EAC or IAC members throughout the year as needed. The Core will coordinate travel, purchase supplies, monitor budgets, handle personnel issues, submit annual progress reports, and facilitate recruitment of new investigators, post docs, and students. As co-directors of this core, Drs. Gauderman and Siegmund will jointly assume responsibility for all organizational and financial activities of the project. In addition, Dr. Gauderman will assume specific leadership of Project activities and Dr. Siegmund specific leadership of Core activities. These Project- and Core-specific roles will guarantee that both important elements of the overall program are being adequately administered. They will also establish the infrastructure needed for effective communications and collaboration across the Projects and Cores. They will co-chair our IAC and plan one annual meeting of the EAC as well as a separate annual scientific retreat with all program and core investigators. Leveraging their experience as Director of the Division of Biostatistics (Dr. Gauderman) and Director of our Biostatistics and Epidemiology Education Program (Dr. Siegmund), they will assure that the ambitious goals of this program are fully coordinated and supported.