Electronic Access to Mouse Tumor Data

我们的总体目标是发展一个支持基本癌症遗传学的信息学基础设施 使用小鼠作为人类癌症模型系统的研究。小鼠肿瘤生物学（MTB） 数据库（tumor.informatics.iax.org）已成为研究人员寻求的主要资源 关于小鼠肿瘤疾病的频率、发病率、遗传学和病理学的综合信息。 MTB强调了在不同遗传定义的肿瘤菌株中特征性发展的肿瘤的数据。 作为人类癌症疾病模型的小鼠（近交、突变和基因工程）。MTB 提供数据以帮助选择用于实验的菌株，并且是挖掘肿瘤数据的平台 转移的发展和模式。 我们现在建议利用这一资源。具体而言： 我们将提高MTB对肿瘤遗传变化数据的覆盖率，包括越来越多的 肿瘤中遗传和基因表达变化的全基因组分析信息。 我们将开发用于探索癌症相关基因的染色体和基于序列的图谱的工具。 易感性和修饰基因座以及肿瘤中发生的体细胞突变。 我们将继续用近交系中肿瘤发生的菌株特异性模式的数据来填充MTB， 突变体和基因工程小鼠，包括肿瘤诊断和组织病理学图像的数据。 我们将通过数据库维护，新的开发， 软件组件、用户支持服务和社区外展活动。 我们的目标是为用户提供关于人类癌症小鼠模型的最新数据，并提供 探索和利用山地车数据的工具，以激发新的假设，可能提供新的见解， 癌症发生和发展的过程。 与公共卫生的相关性：小鼠肿瘤生物学数据库（MTB）是一个可公开访问的互联网 科学界用来帮助选择小鼠品系的资源， 人类癌症的实验模型。研究人员询问MTB关于肿瘤发病率的信息， 关于菌株携带的遗传变异的数据，以及关于在特定的 癌的数据库中的数据管理和表示优先考虑那些作为 主要人类癌症的模型和那些专门开发的新菌株， 人类临床疾病。MTB计划的扩展和可视化工具将进一步增强 小鼠作为理解人类生物学和癌症过程的模型系统的价值。

Our overall goal is to develop an informatics infrastructure essential for supporting basic cancer genetics research using the mouse as a model system for human cancer. The Mouse Tumor Biology (MTB) Database (http://tumor.informatics.iax.org) has become a primary resource for researchers seeking integrated information on the frequency, incidence, genetics, and pathology of neoplastic disorders in mice. MTB emphasizes data on tumors that develop characteristically in different genetically defined strains of mice (inbred, mutant, and genetically engineered) that serve as disease models for human cancers. MTB provides data to assist in selection of strains for experimentation and is a platform for mining data on tumor development and patterns of metastases. We now propose to build on this resource. Specifically: ¿ We will improve MTB's coverage of data on genetic changes in tumors, by including a growing body of information on whole genome profiling of genetic and gene expression changes in tumors. ¿ We will develop tools for exploring chromosomal and sequence-based maps of cancer-associated susceptibility and modifier loci and somatic mutations that occur in tumors. ¿ We will continue to populate MTB with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, including data on tumor diagnoses and histopathology images. ¿ We will support the infrastructure of MTB through database maintenance, development of new software components, user support services, and community outreach activities. Our objective is to provide the user with current data about mouse models for human cancer and provide tools for exploring and exploiting MTB data to inspire new hypotheses that may provide novel insights into the process of cancer initiation and progression. Relevance to Public Health: The Mouse Tumor Biology Database (MTB) is a publicly accessible internet resource that the scientific community uses to assist in selection of mouse strains that will serve as experimental models for human cancer. Researchers interrogate MTB for information on tumor incidence, data on genetic variants carried by strains, and on somatic changes that occur characteristically in specific cancers. Priority for data curation and representation in the database is given to those strains that serve as models for the predominant human cancers and those new strains developed specifically to reflect the human clinical disease. The expansion and visualization tools planned for MTB will further enhance the value of the mouse as a model system for understanding human biology and cancer processes.