Pediatric Hematology and Oncology Research

描述(由申请人提供)：本次竞争性续签申请的目的是为德克萨斯大学达拉斯西南医学中心(UT Southwest)儿科的四名儿科血液肿瘤学研究员(两名二年级和两名三年级)申请继续全国服务研究奖支持。这些奖项将用于支持年轻儿科医生的研究培训，他们已经完成了致力于患者诊断和管理以及接触研究方法的临床团契年。德克萨斯大学西南分校的儿科血液肿瘤学奖学金项目是在20世纪80年代中期发展起来的，旨在培养致力于在学术领域从事全职工作的内科医生，鉴于全国儿科血液肿瘤学临床和实验室学者的持续短缺，这是一项迫切的需求。得克萨斯大学西南分校的这一奖学金培训计划的持续成功是有保证的，因为：(1)大量、多样化和容易获得的患者群体，(2)在癌症治疗、分子肿瘤学、癌症存活率、镰状细胞疾病、出血性和血栓性疾病、肿瘤学支持护理和癌症遗传学等领域的临床和实验室研究卓越记录，(3)与杰出的基础科学研究人员的良好合作和承诺，以及(4)现有的基础设施和以患者为导向的主要机构倡议。这些特点结合在一起，为由所要求的津贴支助的研究员的前沿研究培训提供了一个良好的环境。目前和以前的儿科血液肿瘤学实习生在不同研究领域的研究人员的指导下工作。自1990年首次获奖以来，31名学员得到了NRSA机构的支持，大多数人成功地担任了临床或实验室研究人员，或继续担任研究员。德克萨斯大学西南分校儿科血液肿瘤科及其多个合作实验室和临床研究领域的激动人心的智力参与将继续为学员成为独立研究人员提供必要的丰富环境。

DESCRIPTION (provided by applicant): The purpose of this competitive renewal application is to request continued National Service Research Award support for four pediatric hematology-oncology fellows annually (two second-year and two third-year) in the Department of Pediatrics at The University of Texas Southwestern Medical Center at Dallas (UT Southwestern). These awards will be used to support research training of young pediatricians who have completed a clinical fellowship year devoted to patient diagnosis and management and exposure to research methods. The pediatric hematology-oncology fellowship program at UT Southwestern was developed in the mid-1980's with the broad aim of training physicians committed to full-time careers in the academic arena, a vital need in view of the continued national shortage of clinical and laboratory scholars in pediatric hematology-oncology. The continued success of this fellowship training program at UT Southwestern is assured, given: (1) a large, diverse, and readily accessible patient population, (2) a track record of clinical and laboratory investigative excellence in areas such as cancer therapeutics, molecular oncology, cancer survivorship, sickle cell disease, hemorrhagic and thrombotic disorders, oncologic supportive care, and cancer genetics, (3) well functioning collaborations with and commitment from outstanding basic science investigators, and (4) existing infrastructure and major new institutional initiatives on patient-oriented research. These features combined provide an excellent environment for cutting-edge research training of fellows supported by the requested stipends. Current and former pediatric hematology-oncology trainees have worked under the preceptorship of investigators in diverse research areas. Since the initial award in 1990, thirty-one trainees have received institutional NRSA support and most have been successful as clinical or laboratory investigators or continue as fellows. The stimulating intellectual involvement in the Division of Pediatric Hematology-Oncology and its multiple collaborating laboratories and clinical research domains at UT Southwestern will continue to provide the rich milieu necessary for trainees to become independent investigators.