Research Core

项目总结 几十年的研究未能解决美国本土药物和其他物质使用不平等的问题 各州。这些持续不断的挑战要求新的系统和方法来扭转对土著物质的趋势 使用预防、计划和政策。研究核心将作为方法支持的中心资源 以及对Circle提出的旨在建立资源和证据的研究和评估项目的分析 文化作为治愈和预防药物使用、发病率和死亡率差异的核心来源 这是几个世纪以来殖民者种族创伤和压迫的结果。研究核心由一个团队领导 土著和盟国领导层将在土著研究方法方面提供业务支助； 社区伙伴关系和响应文化的参与；物质使用流行病学；纵向， 定量、定性和混合方法分析；多水平和混合建模；实施科学； 以及数据管理、主权和管理，与Circle的总体目标和目标一致。在……里面 此外，研究核心将提出四个方法创新项目，旨在：(1)概念化和 将“文化”作为解决内部和跨部门问题物质使用的关键概念 土著社区和环境；(2)描述新的成果和衡量方法 原住民成瘾前和康复的概念；(3)加强对异质性的理解 在干预、实施和政策方面，为物质使用研究的精确方法提供信息 土著社区；和(4)通过建立一个 度量和相关资源的存储库。研究核心还将通过以下方式支持创新的试点工作 来自不同学科的早期职业研究人员，并帮助他们将试点研究发展为强大的 外部资助的研究。最后，研究核心将支持传播该圈的 与行政核心合作取得的方法进步和研究成果。

PROJECT SUMMARY Decades of research has failed to address Indigenous drug and other substance use inequities in the United States. These persistent challenges call for new systems and methods to turn the tide on Indigenous substance use prevention, programs, and policies. The Research Core will serve as a central resource for methods support and analyses for CIRCLE's proposed research and evaluation projects designed to build resources and evidence for culture as a core source of healing and prevention of substance use morbidity and mortality disparities resulting from centuries of colonizer-based racial trauma and oppression. The Research Core is led by a team of Indigenous and allied leadership who will provide operational support in Indigenous research methodologies; community partnership and culturally responsive engagement; substance use epidemiology; longitudinal, quantitative, qualitative, and mixed-methods analyses; multilevel and mixture modeling; implementation science; and data management, sovereignty, and stewardship in line with CIRCLE's overall aims and objectives. In addition, the Research Core will advance four methods innovation projects designed to: (1) conceptualize and operationalize “culture” as a key construct for addressing problematic substance use within and across Indigenous communities and settings; (2) characterize novel outcomes and measurement approaches for concepts of pre-addiction and recovery in Indigenous populations; (3) enhance understanding of heterogeneity in interventions, implementation, and policies to inform precision approaches to substance use research with Indigenous communities; and (4) operationalize the Indigenist Ecological Systems Model through creation of a repository of measures and associated resources. The Research Core will also support innovative pilot work by early-career investigators from diverse disciplines and helps them develop pilot research into robust lines of extramurally funded research. Finally, the Research Core will support dissemination of the CIRCLE's methodological advances and research findings in collaboration with the Administrative Core.