Signaling Pathways in Innate Immunity

在相对年轻的“先天免疫”领域，知识出现了前所未有的扩张， COVID揭示的严重炎症表现的潜在机制就是例证- 19大流行。《先天免疫中的信号通路》(SPII)博士后和博士后培训计划(TP) 托拉学员于2022年8月完成第10个年头，本次修订后的申请要求继续提供资金 在11-15年间。马里兰大学医学院(UMSOM)有重要的研究和培训 在这一领域的优势。为这一独特的TP而设的33个培训补助金学院(TGF)具有高度的互动性 主要来自微生物学和免疫学系，在跨学科中心有附属机构 和研究所(例如，疫苗开发中心、基因组科学研究所、血管中心和 炎症性疾病和Greenebaum综合癌症中心)。我们的转化生长因子资金充足，而且 在赠款和出版物方面有很长的合作历史。博士前实习生是从一个强大的 申请者人才库，包括UMSOM医学博士/博士研究生计划的申请者 科学、分子微生物学和免疫学(MMI)计划。培训包括严格的、多学科的 核心课程、特定项目课程、选修课、期刊俱乐部、研讨会、年度研讨会以及 研究生研究论坛。额外的学术工作将与强化的实验室培训相结合。 通过在转化生长因子的指导下进行论文研究，其专业知识将为跨领域和多领域的研究提供支持。 初级培训机会。符合SPII TP资格的博士后研究员越来越多地被实验室吸引 拥有先天性免疫信号方面的专业知识，在那里他们接受专门的指导，使用最先进的Re 在具有学术挑战性的环境中获得新技能的来源和创新机会。前置和 博士后实习生有额外的强制性授课和非授课要求，包括 负责我们中心的研究、专业发展和新的“动手”培训模式 创新生物医学研究(Cibr)核心设施和高度结构化的指导计划。招募- 培训来自代表不足的少数群体的受训人员是该方案的一项优先事项，并反映在 我们的博士后和博士后实习生：在1-10年间，SPII TP实习生中59.6%为女性，22.9%为非女性。 对少数族裔的贬低。SPII TP由一个高度合格的咨询委员会指导，其中包括TP主管和 3名联席董事，2名高级董事，4名前任或现任TP董事。我们支持受训人员参与以下项目- 在严谨性和可重复性、多样性、公平性和包容性方面创新的新培训内容，以及扩大到 促进他们的专业发展。我们目前的实习生已经创造了令人印象深刻的公共记录- 奖项和SPII校友在学术、行业或政府研究职位上，或有连续- 参加过博士后或住院医师培训。到目前为止，他们的成功表明SPII学员的表现格外出色 为科学事业做好准备，这将对国家的健康做出重大贡献。

An unprecedented expansion of knowledge has occurred in the relatively young field of “innate immunity,” as exemplified by the mechanisms underlying the severe inflammatory manifestations revealed by the COVID- 19 pandemic. The “Signaling Pathways in Innate Immunity” (SPII) training program (TP) for pre- and postdoc- toral trainees completed its 10th year in August 2022, and this revised application requests continued funding for years 11-15. The University of Maryland School of Medicine (UMSOM) has significant research and training strengths in this area. The 33 Training Grant Faculty (TGF) for this uniquely focused TP are highly interactive and primarily from the Department of Microbiology & Immunology, with affiliations in interdisciplinary centers and institutes (e.g., Center for Vaccine Development, Institute for Genome Sciences, Center for Vascular and Inflammatory Diseases, and the Greenebaum Comprehensive Cancer Center). Our TGF are well-funded and have a long history of collaboration on grants and publications. Predoctoral trainees are selected from a strong applicant pool, including entrants from the UMSOM M.D./Ph.D. Program, within the Graduate Program in Life Sciences Molecular Microbiology & Immunology (MMI) Program. Training includes a rigorous, multidisciplinary core curriculum, program-specific courses, elective courses, journal clubs, seminars, annual symposia, and graduate research forums. Additional academic work will be combined with intensive laboratory training through dissertation research under the direction of the TGF whose expertise will provide inter- and multidisci- plinary training opportunities. SPII TP-eligible postdoctoral fellows are increasingly gravitating to laboratories with expertise in innate immune signaling where they receive dedicated mentoring using state-of-the art re- sources and innovative opportunities to attain new skills in an academically challenging environment. Pre- and postdoctoral trainees have additional mandatory didactic and non-didactic requirements, including training in the responsible conduct of research, professional development, new “hands on” training modules in our Center for Innovative Biomedical Research (CIBR) Core facility, and a highly structured mentoring program. Recruit- ment of trainees from underrepresented minorities is a priority of the SPII TP and is reflected in the diversity of our pre- and postdoctoral trainees: in Years 1-10, SPII TP trainees were 59.6% women and 22.9% un- derrepresented minorities. SPII TP is guided by a highly qualified Advisory Board including the TP Director and 3 Co-Directors, 2 senior TGF, and 4 past or current TP Directors. Our TGF support trainee participation in in- novative new training components in rigor and reproducibility, diversity, equity and inclusion, and outreach to foster their professional development. Our current trainees are already building impressive records of publica- tions and awards and SPII alumni are in academic, industry, or government research positions or have contin- ued postdoctoral or resident training. Their successes to date indicate that SPII trainees are exceptionally well prepared for scientific careers that will significantly contribute to the nation’s health.