Rigorous Research Principles for Practicing Neuroscientists

项目摘要 在越来越大的尺度上测量神经活动的技术进展， 时间分辨率，伴随着数据存储成本降低，正在推动 神经科学随着神经数据在世界范围内的积累，全球神经科学面临着新的挑战 社区：如何理解这些复杂的数据，以推动生物学的洞察力，并揭示新的光 神经和神经精神障碍。这个新的、数据驱动的神经科学研究时代要求 研究人员掌握严格的研究原则，并知道何时以及如何应用这些原则。 缺乏可用的资源来开发这些严格的研究技术的实践经验， 神经科学为了应对这一当前和日益增长的挑战，我们建议发展教育单位， 专注于严谨研究的具体原则。为了达到最大的目标受众-生物学家， 心理学家和临床医生直接使用神经数据-我们将假设只有一个基本的数学 背景和有限的熟悉计算机编程，共同的那些在生物科学培训。 拟议的教育单位将面向所有职业级别的调查员， 本科研究员建立PI -理解和应用严谨的研究原则， 神经数据通过跨学科的案例研究方法，我们将使用来自神经科学的真实数据 激励严格的研究原则的学习和应用。为了吸引学习者，我们将开发 多媒体材料结合书面文字，简短的视频讲座和计算机编程练习， 促进对材料的动手学习。模块格式将提供多个连贯的学习途径 通过在线内容，从而允许个性化学习的个人与不同的定量 背景和研究兴趣。教育单元的格式也将允许开发的资源， 可广泛获得、传播、可复制，并易于集成到中心框架中。的 拟议的教育单位将为研究人员提供分析所需的基本技能， 神经数据，并提高整个研究中严格研究原则的一般能力 劳动力

PROJECT SUMMARY Advances in technology for measuring neural activity at ever-larger scales and with increasing spatial and temporal resolution, concomitant with a decrease in costs of data storage, are driving a revolution in neuroscience. As neural data accumulates worldwide, a new challenge faces the global neuroscience community: how to make sense of these complex data to drive biological insight and to shed new light on neurological and neuropsychiatric disorders. This new, data-driven era of neuroscientific research demands that investigators master rigorous research principles and know when and how to apply these principles. Accessible resources to develop hands-on experience with these rigorous research techniques are lacking in neuroscience. To address this current and growing challenge, we propose to develop educational units focused on specific principles of rigorous research. To reach the largest target audiences - the biologists, psychologists, and clinicians working directly with neural data - we will assume only a basic mathematics background and limited familiarity with computer programing, common to those trained in biological sciences. The proposed educational units will target investigators at all career levels - spanning from the beginning undergraduate researcher to the established PI - to understand and apply principles of rigorous research to neural data. Through an interdisciplinary case-study approach, we will use real-world data from neuroscience to motivate the study and application of rigorous research principles. To engage learners, we will develop multimedia material combining written text, short video lectures, and computer programming exercises, that promote hands-on learning of the material. The modular format will provide multiple coherent learning paths through the online content, and thereby allow personalized learning for individuals with varying quantitative backgrounds and research interests. The educational unit format will also permit the developed resources to be widely available, disseminated, and discoverable, and easily integrated into the CENTER framework. The proposed educational units will prepare researchers with the fundamental skills required for the analysis of neural data and elevate the general competencies in rigorous research principles across the research workforce.