Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection

项目总结/文摘

Project Summary/Abstract The filoviruses, Ebola and Marburg viruses (EBOV and MARV), are emerging, negative-strand RNA viruses associated with outbreaks of severe viral hemorrhagic fever. The virulence and emerging nature of these zoonotic pathogens makes them a significant threat to human health, potential agents of bioterrorism, and NIAID category A priority pathogens. The overall goal of the parent R01 application is to characterize EBOV VP30 (eVP30), a key viral protein that facilitates viral transcription, and its interactions with host factors. This supplement request in response to PA-21-071 - Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) will support the training and career development of trainee currently enrolled in a medical student training program to develop her career as a physician scientist. Scientific research program, which extends protein-protein interaction and post translational modification studies will map the ubiquitination of filoviral proteins. These proposed efforts will enhance our understanding of filoviral-host interactions and provide an opportunity for career development.