Administrative Core

核心A--项目摘要/摘要 丝状病毒是重要的新兴生物防御性病原体，有可能影响全球健康。这个 此续订计划项目拨款(PPG)申请的首要目标是确定宿主病毒的特征 有助于丝状病毒感染的相互作用，确定分子相互作用，并发展对 分子机制。这个跨学科的项目将提供对驱动丝状病毒的宿主相互作用的洞察力 并确定新的治疗靶点。这项由多名调查员合作的工作将在 几个站点和行政核心(核心A)将提供行政监督和协调 网站之间的互动，以确保这一综合研究计划的进展将最大化。堆芯 A Will：1.通过虚拟会议和电话会议协调研究人员之间的沟通 项目和科学核心，每月基于网络的研究进展会议和年度会议 在所有参与团体的成员中。这些会议将促进试剂和科学交流 在不同的地点之间。2.协调调查员与外部咨询人之间的年度会议 委员会(EAB)评估科学进展并促进关键评估的分发 PPG的表现。3.管理利益冲突，促进冲突解决。4.协调财政 管理和科学核心的使用，以确保研究项目得到很好的支持。5.便利 通过实施基于云的解决方案，确保数据共享和访问CORE开发的试剂库存 商业数据库平台。6.协助调查人员准备和提交年度进展 向美国国家卫生研究院提交报告，并维护一个数据传播网站。7.确定培训和培训机会 为PPG小组内的受训人员提供专业发展，促进他们的参与和促进交叉 培训和专业知识分享。通过这些集体行动，核心A将促进科学互动和 为整个科学任务的无缝运作提供支持，以发现和确定关键宿主- 病毒相互作用对丝状病毒感染至关重要。

Core A – Project Summary/Abstract Filoviruses are important emerging and biodefense pathogens with potential to impact global health. The overarching goal of this renewal Program Project Grant (PPG) application is to characterize host-viral interactions that contribute to filoviral infection, identify molecular interactions, and develop insights into molecular mechanisms. This interdisciplinary project will provide insight into host interactions that drive filoviral infections and identify new therapeutic targets. This multi-investigator collaborative effort will be conducted at several sites and the Administrative Core (Core A) will provide administrative oversight and coordinate interactions among sites to ensure that progress of this integrated research program will be maximized. Core A will: 1. Coordinate communication by virtual meetings and teleconferences among the PIs of the Research Projects and Scientific Cores, monthly web-based research-in-progress meetings, and an annual meeting among members of all participating groups. These meetings will facilitate reagent and scientific exchange among the different sites. 2. Coordinate annual meetings between the investigators and the External Advisory Board (EAB) to assess scientific progress and to facilitate the distribution of critical evaluations on the performance of the PPG. 3. Manage conflicts of interest and facilitate conflict resolution. 4. Coordinate fiscal administration and Scientific Core usage to ensure that the research projects are well supported. 5. Facilitate secure data sharing and access to inventory of reagents developed by Cores by implementing a cloud-based commercial database platform. 6. Assist investigators with preparation and submission of annual progress reports to the NIH and maintain a website for data dissemination. 7. Identify opportunities for training and professional development for trainees within the PPG group and facilitate their participation and promote cross training and expertise sharing. Through these collective actions, Core A will promote scientific interactions and provide support for seamless functioning of the overall scientific mission to discover and characterize key host- viral interactions that are critical for filoviral infections.