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中文摘要
翻译
描述(由申请人提供):认知功能的丧失是众所周知的,虽然它与阿尔茨海默病和其他与年龄相关的痴呆症中所见的灾难性记忆丧失明显不同,但它受到越来越多美国人的关注。本申请旨在为哥伦比亚大学陶布研究所招募一名优秀的初级教员,研究动物或人类大脑的正常衰老过程。
英文摘要
DESCRIPTION (provided by applicant): The loss of cognitive function with normal aging is well known and while clearly different from the catastrophic loss of memory seen in Alzheimer's disease and the other age-related dementias, is of concern to an increasing number of Americans. This application seeks support to recruit an outstanding junior faculty member to the Taub Institute at Columbia University to study the normal aging process in either the animal or the human brain. PUBLIC HEALTH RELEVANCE: An understanding of the mechanisms of normal aging in the brain is critical if we are to slow cognitive decline in our aging population. It will enable us to understand the factors that lead to accelerated cognitive decline and dementia.
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Targeting Caspase-2 in Alzheimer's Disease
Targeting Caspase-2 in Alzheimer's Disease
Prospective Purification of Adult Stem Cell Astrocytes
Faculty recruitment on the Neurobiology of Aging