MOSAIC: Administrative Core

摘要：行政核心 马约/哥伦比亚多学科社区生物多样性公约的总体目标是建立一个概念框架， 了解发生在神经胶质瘤中的组织状态转换以及解释磁共振成像的方法 (MRI)与这些关键细胞表型的变化相关。实现这一目标需要多方面的努力， 多方面的方法反映在多个项目和核心被提议。行政核心将是 提案所有部分的主要接触点，监督工作以有效的方式完成， 提供必要的行政支助，以协调所有努力。我们CSBC的中心工作是 围绕由生物样本收集、处理和存储的图像定位活检的广泛分析 核心，由数据集成和计算核心分析，并在项目1和2之间共享。这 将积极地对GBM患者的图像定位活检与临床成像进行高度集成的分析， 由行政核心管理，以确保顺利的实验流程，强调质量， 再现性 我们设想MOSAIC将作为围绕组织主题的合作纽带 跨联盟的状态转换和临床成像，以及其他癌症的可能兴趣领域， 胶质瘤行政核心的一个关键职能是通过以下方式积极促进这种合作： 与我们的外展核心协调，特别是通过管理中心内和跨联盟试点 项目，举办讲习班和研讨会，并促进访问教师，同时提高多样化 对这一关键问题的看法。这些活动将扩大到有关机构之间的合作 在马约/哥伦比亚CSBC以及CSBC和PSON内U 54和U 01持有者之间的合作 网络. 在行政核心中，我们的目标是管理中心的后勤和通信，管理中心内的 试点项目，并建立和支持外部咨询委员会-将支持我们的各个方面， 应用程序.斯旺森和卡诺尔将在行政核心中发挥中央领导作用， 中心项目管理员将提供日常业务、行政和科学管理， 中心活动。

SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in glioma and the ways to interpret magnetic resonance imaging (MRI) relative to those changes for these key cellular phenotypes. Achieving this objective will require a multi- faceted approach reflected by the multiple projects and cores being proposed. The administrative core will be the primary touchpoint for all pieces of the proposal, overseeing that work is done in an efficient way and providing the necessary administrative support to coordinate all efforts. The central work for our CSBC revolves around extensive analysis of image-localized biopsies that are collected, processed, and stored by Biospecimen Core, analyzed by the Data Integration and Computation Core, and shared between Projects 1 and 2. This highly integrated analysis of image-localized biopsies from GBM patients with clinical imaging will be actively managed by the Administrative Core to ensure a smooth experimental flow with an emphasis on quality and reproducibility. We envision that MOSAIC will serve as a nexus for collaborations focused on the topics revolving around tissue state transitions and clinical imaging across the consortium with likely areas of interest in other cancers beyond glioma. A key function of the Administrative Core will be to actively cultivate such collaborations through coordination with our Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse perspectives on this critical topic. These activities will extend both to collaborations between institutions involved in the Mayo/Columbia CSBC and collaborations across the U54 and U01 holders within the CSBC and PSON networks. In the Administrative Core, our aims—to manage center logistics and communication, administer Intra-Center Pilot Projects, and create and support the External Advisory Committee—will support all aspects of our application. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business, administrative and scientific management of Center activities.