Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans

摘要 亚裔和太平洋裔美国人(APA)在美国所有种族/民族中经历了最大的增长 美国在2000年至2020年之间。在纽约市/新泽西州(NYC/NJ)地区，年长(65岁以上)的亚裔印第安人和 华裔美国人口在过去十年中分别增长了73%和74%。而基于索赔的 此前在美国的研究表明，阿尔茨海默病(AD)及其相关疾病的患病率较低 痴呆(ADRD)在老年APA中，这一发现可能是由于与NOT相关的诊断不足所致 具有文化上和语言上合适的工具、临床医生或系统。具有AD/ADRD的较旧APA 因此，美国面临着诊断不足和整体护理提供不足的问题，即使是在 在APA亚组内部和之间存在着巨大的差异。更重要的是，新冠肺炎大流行和 相关的反亚洲歧视给年长的中国人和非中国人带来了更大的社会孤立 成年人在过去的三年里比其他群体更多。这些因素共同构成了 亚太美国人阿尔茨海默病和痴呆症研究资源中心(RCASIA) 1)越来越多的科学家在AD/ADRD相关的行为、社会和经济领域任职人数不足 通过创新的指导和社区互动模式研究生物医学研究；2) 通过共同数据元素和共同数据推动AD/ADRD试点研究在较旧的APA中的严密性和影响 数据共享；3)作为国家资源，提供经过语言/文化检验和验证的评估工具 APA人群的认知、功能与AD/ADRD护理聚焦人民、文化、 地点、时间、RCASIA将利用强大的机构支持和关系来征集试点申请 来自早期调查人员(Esis)。我们会积极参与和鼓励教育资助计划的申请。 纽约/新泽西州的少数民族服务机构通过申请前RCASIA实习和合作伙伴关系 来自大型资助研究的承诺，预期招募分散的老年行动方案。科学家 指导将在研究教育部分进行(由一名回归的REC核心领导和一名新的 招聘但已建立的AD/ADRD教育/心理社会核心领导)涉及指导/基于方法 豆荚和基于种族的团队。REC将得到领导和行政核心，即 在选择每年的班级时，测量和分析核心，以及社区联系和招募核心 RCASIA科学家，加强豆荚的多代方法和职业发展，指挥 与团队中的社区和生活顾问进行跨学科接触，并评估以下项目的结果 科学家，吊舱/团队模式的有效性，通用数据元素和数据共享的影响，以及 RCASIA和资助科学家之间的长期关系。归国和新入职教师对 多样性、公平性、包容性、可获得性和APA大脑健康将有助于RCASIA成为 老年APA人群AD/ADRD相关行为、社会和经济研究中心。

ABSTRACT Asian and Pacific Americans (APAs) have undergone the greatest growth among all racial/ethnic groups in the U.S. between 2000 and 2020. In the New York City/New Jersey (NYC/NJ) area, older (65+) Asian Indian and Chinese American populations have increased by 73% and 74% over the past ten years. While claims-based studies in the U.S. have previously suggested lower prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) in older APAs, this finding may have resulted from underdiagnosis associated with not having culturally and linguistically appropriate tools, clinicians, or systems. Older APAs with AD/ADRD in the U.S. thus face both the problem of under-diagnosis and under-provision of care as a whole, even as great disparities exist within and between APA subgroups. What’s more, the COVID-19 pandemic and the associated anti-Asian discrimination brought greater social isolation to older Chinese and non-Chinese APA adults over the past three years than other groups. These factors together formed the foundation of the Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) with missions of 1) increasing scientists underrepresented in AD/ADRD-related Behavioral, Social, and Economic Research biomedical research through innovative models of mentoring and community interaction; 2) advancing the rigor and impact of AD/ADRD pilot studies in older APAs through Common Data Elements and data-sharing; 3) serving as a national resource for linguistically/culturally tested and validated tools to assess cognition, function, and AD/ADRD care in APA populations. Focusing on the theme of People, Culture, Place, Time, RCASIA will leverage strong institutional support and relationships to solicit pilot applications from Early Stage Investigators (ESIs). We will actively engage and encourage applications from ESIs at NYC/NJ-based Minority Serving Institutions through pre-application RCASIA internships and partnership commitments from large funded studies prospectively recruiting disaggregated older APAs. Scientist mentoring will occur in the Research Education Component (co-led by a returning REC Core Lead and a newly recruited yet established AD/ADRD Education/Psychosocial Core Lead) involving mentoring/method-based Pods and ethnicity-based Teams. REC will be supported by the Leadership & Administrative Core, the Measurement & Analytical Core, and Community Liaison & Recruitment Core in selecting each year’s class of RCASIA Scientists, enhancing multi-generational method and career development in Pods, conducting transdisciplinary engagement with Community & Lived Advisors in Teams, and evaluating the outcomes of Scientists, effectiveness of the Pod/Team model, impact of Common Data Elements and data sharing, and long-term relationships between RCASIA and funded Scientists. Returning and new faculty’s commitment to diversity, equity, inclusion, and access and APA brain health will contribute to RCASIA’s goal of becoming the epicenter for AD/ADRD-related Behavioral, Social, and Economic Research in older APA populations.