Neurological and digital correlates of cognition in Older Mandarin-speaking Adults
普通话老年人认知的神经和数字相关性
基本信息
- 批准号:10608780
- 负责人:
- 金额:$ 223.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-15 至 2025-11-30
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcculturationAdultAgingAlzheimer associated neurodegenerationAlzheimer&aposs DiseaseAmericasAnimalsAnteriorAreaArticulationAsianAsian AmericansBehavioralBiological MarkersBloodCaliforniaCerebrovascular DisordersChicagoChinaChineseChinese populationClinicalClinical TrialsCognitionCognitiveCommunitiesData SetDementiaDetectionDiagnosisDiagnosticDigit structureDiseaseDisparateEarly InterventionElderlyEligibility DeterminationEnrollmentEquityEuropeExposure toFDA approvedFamiliarityFrequenciesGenerationsGoalsHealthHigh PrevalenceHomeImageImpaired cognitionIncidenceInstructionInternationalKnowledgeLanguageLinguisticsLow PrevalenceMagnetic Resonance ImagingMeasuresMedialMediatingMemoryMinorityNerve DegenerationNeuroanatomyNeurocognitiveNeurologicNeurologistNeuropsychological TestsNeuropsychologyParticipantPerformancePersonsPlasmaPopulation StudyPrevalenceResearchResolutionResourcesRestRetrospective StudiesSemanticsSeverity of illnessTabletsTemporal LobeTestingTrail Making TestTrainingTranslatingTranslationsValidity and ReliabilityWhite Matter Hyperintensitybilingualismcerebral atrophyclinical diagnosisclinical trial enrollmentcognitive functioncognitive reservecognitive testingdementia riskdigitaldigital measuredigital platformdisease phenotypegray matterhealth care availabilityhealth disparityhealth equityhealthy agingimprovedinsightinstrumentliteracymild cognitive impairmentneuroprotectionnonEnglish languagenormal agingnovelpostersrecruitsocial stigmasoundtoolwhite matter
项目摘要
ABSTRACT Asian Americans are the fastest growing demographic group in the US, with
Chinese now representing the third most common language spoken after English and Spanish.
Diagnosis-based studies have shown reduced dementia risks among older Chinese adults in
the US and China, but assessment-based studies have suggested significant under-diagnosis
by 50% or more. A major problem in diagnosis is the lack of reliable tools to diagnose mild
cognitive impairment (MCI) or dementia (including Alzheimer’s disease [AD]) among Chinese
adults in the US: about half of Chinese neuropsychological tests were created through content-
only translation without adjustment for cultural, linguistic, or neurological factors, while the
remaining only have translated instructions. Because language-independent neuropsychological
tests are limited in scope and resolution, detection of MCI/AD in older US Chinese adults is
often delayed for early intervention, clinical trial enrollment, and initiation of disease-modifying
therapies. Building on the unparalleled bilingual neurocognitive expertise at Rutgers and
Stanford, we have developed new Mandarin-based neuropsychological tests accounting for
cognition-related differences between Mandarin and English to mirror the National Alzheimer’s
Coordinating Center assessments. These include: articulation-normalized forward digit span;
articulation- and lexeme-adjusted Craft Story 21; lexeme- and frequency-adjusted word list
recall; Mandarin-specific word generation tasks guided by character, phoneme/pinyin, and
homonym (one character sound corresponding to multiple characters); and exposure-based
Trail Making Test B. We leveraged our existing community relationships to demonstrate the
feasibility and reliability of using these tools in older Mandarin speakers, and we will further
expand their reliability and relationship to performance using English instruments by bilingual
older adults (Aim 1); determine construct and diagnostic validity analysis accounting for
imaging and plasma biomarkers of neurodegeneration (Aim 2); and determine if bilingualism
mediates the effects of neurodegeneration (Aim 3). We will additionally transfer these tests onto
a digital platform which can then be used by centers without Mandarin-speaking clinicians, and
explore the feasibility of longitudinal neuropsychological, blood, and MRI analysis in a subset of
the older Chinese adults. Through this effort, we will provide the first linguistically, culturally,
and neuroanatomically appropriate cognitive tests for Mandarin speakers to enhance clinical
detection of MCI/AD, enable equitable enrollment into clinical trials, reduce language-associated
health disparities, and determine if bilingualism is neuroprotective among Mandarin speakers.
亚裔美国人是美国增长最快的人口群体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William Tzu-lung Hu其他文献
William Tzu-lung Hu的其他文献
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{{ truncateString('William Tzu-lung Hu', 18)}}的其他基金
Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans
亚太裔美国人阿尔茨海默病和痴呆症研究资源中心
- 批准号:
10730059 - 财政年份:2023
- 资助金额:
$ 223.61万 - 项目类别:
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
雌二醇和相关激素对炎症、睡眠和阿尔茨海默病风险的作用
- 批准号:
10663189 - 财政年份:2019
- 资助金额:
$ 223.61万 - 项目类别:
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
雌二醇和相关激素对炎症、睡眠和阿尔茨海默病风险的作用
- 批准号:
10017867 - 财政年份:2019
- 资助金额:
$ 223.61万 - 项目类别:
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
雌二醇和相关激素对炎症、睡眠和阿尔茨海默病风险的作用
- 批准号:
10458043 - 财政年份:2019
- 资助金额:
$ 223.61万 - 项目类别:
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
雌二醇和相关激素对炎症、睡眠和阿尔茨海默病风险的作用
- 批准号:
10240604 - 财政年份:2019
- 资助金额:
$ 223.61万 - 项目类别:
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
雌二醇和相关激素对炎症、睡眠和阿尔茨海默病风险的作用
- 批准号:
9891680 - 财政年份:2019
- 资助金额:
$ 223.61万 - 项目类别:
Transfer RF1 AG054991 Beyond Haploinsuffiency- Gain of Function in Prograulin Mutations
转移 RF1 AG054991 超越单倍体不足 - Prograulin 突变的功能获得
- 批准号:
10399043 - 财政年份:2019
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CSF, MRI, and PET biomarkers of neuroinflammation in Alzheimer's disease
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- 批准号:
9976071 - 财政年份:2016
- 资助金额:
$ 223.61万 - 项目类别:
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