CORE-001 - OPERATIONS CORE

运营核心(OC)通过招募老年人来支持对多因素老年疾病的研究 他们是多样化和有代表性的，让社区的老年人作为利益相关者参与，监测 参与者的安全，提供支持老龄化研究的资源，设计电子数据收集系统- 产生高质量数据的项目，开发支持研究工作流程和分析的软件应用程序， 以及收集、准备和报告说明多因素老龄化研究复杂性的数据。 OC(RC1)的总体目标是确保多因素衰老研究的成功实施。 这一目标将通过领导与伊斯兰会议组织调查人员和研究人员的协调努力来实现。这个 奥委会的具体目标是：(1)提供服务，以实现OAIC资助的目标和其他老龄化-FO-FO CUD研究项目和基础设施以支持领导这些项目的研究人员；(2)合作 改进现场、数据管理和信息学方法，以推进以老龄化为重点的研究 多因素老年疾病，并促进下一代以老龄化为重点的研究的发展- (3)开展创新发展项目，推进耶鲁OAIC的使命。 在本资助周期(2018年至今)，奥委会为16个OAIC资助的项目提供了研究支持 项目和35个外部项目，就实地和数据管理计划咨询了116名耶鲁大学调查人员 对于提交的项目和赠款，获得了NIH补充资金，以构建一套创新的软件- Ware Tools称为耶鲁研究支持套件，并与其他胡椒中心和NIA-SPON合作- 审查研究项目、举办教育研讨会和软件传播。这些业主委员会 这些努力产生了129种出版物和30多笔外部资助赠款，总额超过1.5亿美元-- 狮子。在下一个资金周期中，奥委会将：(1)在6个拟议的区域经济合作和环境保护中心项目中的5个项目上进行合作 和40个资助的外部项目中的34个；(2)指导组织委员会的新研究人员；(3)完善和调整服务-- (4)就研究操作、报告和合规性向调查人员提供建议和支持。 符合国家卫生研究院的要求；(5)通过传播创新的软件产品扩大核心的影响； 以及(6)通过与OAIC协调中心合作，加强我们的研究信息学基础设施，以了解- 确定资金来源，以允许进一步扩大耶鲁学习支持套件(YES3)。YES3 软件将作为OAIC项目研究业务支持的一个组成部分，并将继续扩大-- SION通过拟议的开发项目(DP-1)，将提供更多的分析、报告和 监控。DP-1的目标是建造YES3 Datamart RedCap外部模块(EM)，创新的软- 将与YES3 Exporter集成的Ware，YES3 Exporter是在当前融资周期内开发的新兴市场。新的 Datamart EM将进一步支持对OAIC研究的分析、监控和报告，并将设计为 与未来与赞助商和监管机构共享数据的YES3组件兼容。

The Operations Core (OC) supports research on multifactorial geriatric conditions by recruiting older adults who are diverse and representative, engaging older adults from the community as stakeholders, monitoring the safety of participants, offering resources to support aging research, designing electronic data collection sys- tems that result in high-quality data, developing software applications to support study workflow and analysis, and collecting, preparing and reporting data that account for the complexity of multifactorial aging research. The overall goal of the OC (RC1) is to ensure the successful implementation of multifactorial aging research. This goal will be accomplished by leading coordinated efforts with OAIC investigators and research staff. The Specific Aims of the OC are to: (1) provide services to achieve the aims of OAIC-funded and other aging-fo- cused research projects and the infrastructure to support investigators leading these projects; (2) collaborate to improve field, data management and informatics methodologies needed to advance aging-focused research on multifactorial geriatric conditions and to foster the development of the next generation of aging-focused investi- gators; and (3) conduct innovative Development Projects that advance the mission of the Yale OAIC. During the current funding cycle (2018-present), the OC provided research support for 16 OAIC-funded projects and 35 External Projects, consulted with 116 Yale investigators on field and data management plans for projects and grant submissions, was awarded NIH supplemental funding to build an innovative suite of soft- ware tools called the Yale Study Support Suite, and collaborated with other Pepper Centers and NIA-spon- sored programs on research projects, delivery of educational seminars, and software dissemination. These OC efforts have resulted in 129 publications and more than 30 extramurally funded grants totaling over $150 mil- lion. During the next funding cycle, the OC will: (1) collaborate on 5 of the 6 proposed REC and PESC projects and 34 of the 40 funded External Projects; (2) mentor new research staff in the OC; (3) refine and adapt ser- vices to meet program needs; (4) advise and support investigators on study operations, reporting, and compli- ance with NIH requirements; (5) broaden the impact of the core by disseminating innovative software products; and (6) enhance our research informatics infrastructure by working with the OAIC Coordinating Center to iden- tify funding sources that will permit the further expansion of the Yale Study Support Suite (YES3). The YES3 software will serve as an integral part of study operations support for OAIC projects, and with continued expan- sion through the proposed Development Project (DP-1), will provide additional tools for analysis, reporting, and monitoring. The goal of DP-1 is to build the YES3 Datamart REDCap External Module (EM), innovative soft- ware that will integrate with the YES3 Exporter, an EM developed during the current funding cycle. The new Datamart EM will further support analysis, monitoring, and reporting of OAIC studies and will be designed to be compatible with future YES3 components that share data with sponsor and regulatory agencies.